摘要
目的:观察血清低密度脂蛋白胆固醇(LDL-C)、血小板反应蛋白2(TSP2)、P物质水平联合检测预测高血压脑出血(HICH)血肿扩大的价值。方法:选取2021年1月至2023年3月该院收治的107例HICH患者进行前瞻性研究。依据其住院时期血肿是否扩大分为扩大组32例和未扩大组75例,比较两组入院时血清LDL-C、TSP2、P物质水平;采用受试者工作特征(ROC)曲线分析血清LDL-C、TSP2、P物质水平联合检测预测HICH血肿扩大的价值;分析不同血清LDL-C、TSP2、P物质水平HICH患者发生血肿扩大的危险度。结果:入院时,扩大组血清LDL-C、P物质水平均低于未扩大组,TSP2水平高于未扩大组,差异有统计学意义(P<0.05);ROC曲线分析结果显示,入院时血清LDL-C、TSP2、P物质水平联合预测HICH患者出现血肿扩大的AUC为0.900,高于各指标单项检测;危险度分析结果显示,高水平血清LDL-C、TSP2、P物质HICH患者相对于低水平,发生血肿扩大的RR值为0.464、3.995、0.377(P<0.05)。结论:血清LDL-C、TSP2、P物质水平联合检测预测HICH血肿扩大的价值高于三者单项检测。
Objective:To observe value of combined detection of serum low density lipoprotein cholesterol(LDL-C),platelet reactive protein 2(TSP2),and substance P levels in prediction of hematoma enlargement of patients with hypertensive intracerebral hemorrhage(HICH).Methods:A prospective study was conducted on 107 HICH patients admitted to the hospital from January 2021 to March 2023.According to whether the hematoma expanded during hospitalization,they were divided into enlargement group(32 cases)and an non-enlargement group(75 cases).The serum levels of LDL-C,TSP2,and substance P between the two groups at admission were compared.The value of combined detection of serum LDL-C,TSP2,and substance P levels in the prediction the hematoma enlargement of the patients with HICH was analyzed by using receiver operating characteristic(ROC)curve analysis.Further,the risk degrees of hematoma enlargement in the HICH patients with different serum levels of LDL-C,TSP2,and substance P were analyzed.Results:At admission,the serum LDL-C and substance P levels in the enlargement group were lower than those in the non-enlargement group,while the TSP2 level was higher than that in the non-enlargement group,and the differences were statistically significant(P<0.05).The ROC curve showed that the AUC of the combined prediction of LDL-C,TSP2,and substance P levels at admission for hematoma enlargement in the HICH patients was 0.900,which was higher than the single detection of each indicator.The RR values of hematoma enlargement in HICH patients with high levels of serum LDL-C,TSP2 and substance P were 0.464,3.995 and 0.377,respectively(P<0.05).Conclusions:The value of combined detection of serum LDL-C,TSP2,and substance P levels in the prediction of hematoma enlargement of the patients with HICH is higher than the single detection of the three.
作者
任森
REN Sen(Department of Neurological Intensive Care(Surgery)of Nanyang Central Hospital,Nanyang 473000 Henan,China)
出处
《中国民康医学》
2023年第21期104-106,共3页
Medical Journal of Chinese People’s Health
