摘要
目的探讨计算机断层扫描(CT)引导下放射性^(125)I粒子植入联合肝动脉化疗栓塞(TACE)+射频消融治疗肝包膜下小肝癌的价值。方法选取2020年1月-2022年2月收治的80例肝包膜下小肝癌患者,随机分为观察组和对照组各40例,对照组采用TACE+射频消融术治疗,观察组在对照组的基础上采用CT引导下^(125)I粒子植入治疗,比较两组客观缓解率(ORR)、肝功能[谷丙转氨酶(ALT)、天冬氨酸转氨酶(AST)和总胆红素(TBil)]、血清肿瘤标志物[甲胎蛋白(APF)、癌胚抗原(CEA)]、不良反应以及无进展生存率。结果观察组ORR高于对照组(85.00%vs 62.50%,χ^(2)=5.230,P<0.05);两组ALT、AST、TBil水平比较,差异无统计学意义(P>0.05);治疗后,观察组APF、CEA水平低于对照组(t=7.616;t=8.938,P<0.05);两组不良反应水平比较,差异无统计学意义(P>0.05);观察组1年无进展生存率为80.00%,高于对照组的50.00%(Log Rankχ^(2)=7.487,P<0.05)。结论CT引导下^(125)I粒子植入联合TACE+射频消融治疗肝包膜下小肝癌的疗效显著,可有效降低血清肿瘤标志物水平,提高无进展生存率,且安全性较好。
Objective To explore the value of computed tomography(CT)-guided radioactive ^(125)I seed implantation combined with transcatheter arterial chemoembolization(TACE)+radiofrequency ablation in the treatment of subcapsular small liver cancer.Methods A total of 80 patients with subcapsular small liver cancer were enrolled as the research objects between January 2020 and February 2022.They were randomly divided into observation group and control group,40 cases in each group.The control group was treated with TACE+radiofrequency ablation,while observation group was additionally treated with CT-guided^(125)I seed implantation.The objective remission rate(ORR),liver function indexes[alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil)],serum tumor markers[alpha-fetoprotein(APF),carcinoembryonic antigen(CEA)],adverse reactions and progressionfree survival(PFS)were compared between the two groups.Results The ORR in observation group was higher than that in control group(85.00%vs 62.50%,χ^(2)=5.230,P<0.05).There was no significant difference in ALT,AST or TBil between the two groups(P>0.05).After treatment,APF and CEA in observation group were lower than those in control group(t=7.616;t=8.938,P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).The 1-year progressionfree survival rate in observation group was higher than that in control group(80.00%vs 50.00%,Log Rankχ^(2)=7.487,P<0.05).Conclusion The curative effect of CT-guided^(125)I seed implantation combined with TACE+radiofrequency ablation is significant on subcapsular small liver cancer,which can effectively reduce levels of serum tumor markers and improve progression-free survival rate,with good safety.
作者
王健庄
崔创撑
WANG Jian-zhuang;CUI Chuang-cheng(Department of Nuclear Medicine,3201 Hospital,Hanzhong 723000,Shaanxi Province,China;Department of radiology,the Ninth Hospital Of Xi'an,Xi'an 710054,Shaanxi Province,China)
出处
《中国CT和MRI杂志》
2024年第2期111-113,共3页
Chinese Journal of CT and MRI
基金
陕西省重点研发计划项目(2021SF-044)。
关键词
小肝癌
放射性^(125)I粒子
肝动脉化疗栓塞
射频消融术
Small Liver Cancer
Radioactive^(125)I Seed
Transcatheter Arterial Chemoembolization
Radiofrequency Ablation
