摘要
目的中晚期肝癌由于错过了手术机会,临床常采用经皮穿刺肝动脉化疗栓塞(TACE)、射频消融(RFA)治疗等方法介入治疗,本研究探讨TACE联合RFA治疗中晚期肝癌的临床效果,为临床中晚期肝癌治疗提供参考。方法选取2014-01-01-2016-12-31本院收治的96例中晚期原发性肝癌患者,按照组间基本特征均衡可比的原则分为对照组和观察组,每组48例,对照组给予TACE治疗,观察组给予TACE联合RFA治疗,比较两组患者治疗效果、不良反应发生情况及生存率。结果观察组治疗有效率为91.67%,高于对照组的77.08%,差异有统计学意义,χ2=3.872,P=0.049。观察组患者发热、恶心、肝区疼痛、消化功能异常和穿刺部位血肿不良反应发生率分别为31.25%、43.75%、33.33%、47.92%和25.00%,与对照组的27.08%、35.42%、29.17%、41.67%和27.08%比较,差异无统计学意义,均P>0.05。观察组1年生存率为75.00%,高于对照组的52.08%,χ2=5.441,P=0.020;2年生存率为47.92%,高于对照组的27.08%,χ2=4.444,P=0.035;3年生存率为22.92%,高于对照组的8.33%,χ2=3.872,P=0.049。结论TACE联合RFA治疗中晚期肝癌患者治疗效果好,安全性较高,可延长患者生存期。
Objective Interventional treatments such as percutaneous transhepatic arterial chemoembolization(TACE)and radiofrequency ablation(RFA)are often used for intermediate and advanced liver cancer due to missed opportunities for surgery.This study aimed to explore the clinical effect of TACE combined with RFA in the treatment of intermediate and advanced liver cancer,provided reference for liver cancer treatment.Methods A total of 96 patients with intermediate and advanced primary liver cancer admitted to our hospital from January 1,2014 to December 31,2016,were divided into control group and observation group according to the principle of balanced and comparable basic characteristics between groups,with 48 cases in each group.The control group was treated with TACE,and the observation group was treated with TACE and RFA.The treatment effects,adverse reactions and survival rates of the two groups were compared.Results The effective rate of treatment in the observation group was 91.67%,which was higher than that of the control group(77.08%),the difference was statistically significant,χ2=3.872,P=0.049.The incidence of adverse reactions of fever,nausea,liver pain,abnormal digestive function,and hematoma at the puncture site in the observation group were31.25%,43.75%,33.33%,47.92%and 25.00%,compared with 27.08%,35.42%,29.17%,41.67%and 27.08%in the control group,the difference was not statistically significant,all P>0.05.The 1-year survival rate of the observation group was 75.00%,which was higher than that of the control group(52.08%),χ2=5.441,P=0.020.The 2-year survival rate was 47.92%,which was higher than the control group’s 27.08%,χ2=4.444,P=0.035.The 3-year survival rate was 22.92%,which was higher than that of the control group(8.33%),χ2=3.872,P=0.049.Conclusion TACE combined with RFA in the treatment of patients with intermediate and advanced liver cancer has a good therapeutic effect and high safety,which can prolong the survival time of patients.
作者
王秀娟
魏林
WANG Xiu-juan;WEI Lin(Department of Intervention,First People's Hospital of Zhumadian City,Zhumadian463000,China)
出处
《社区医学杂志》
CAS
2021年第1期32-35,共4页
Journal Of Community Medicine
关键词
经皮穿刺肝动脉化疗栓塞
射频消融
肝癌
生存率
percutaneous hepatic artery chemoembolization
radiofrequency ablation
liver cancer
survival rate
