摘要
目的探讨网织红细胞及血清总胆红素(TBi L)联合溶血三项在新生儿溶血病中的临床诊断价值。方法对安阳市中医院2019年10月至2022年10月收治的140例疑似新生儿溶血病的新生儿患者的临床资料进行回顾性分析,以临床确诊为标准,将所有患儿分为非新生儿溶血病组(40例)和新生儿溶血病组(100例)。检测两组患儿溶血三项、网织红细胞及血清TBi L。分析溶血三项的检测结果,对比溶血三项检查与临床确诊新生儿溶血病的结果,将新生儿溶血病组和非新生儿溶血病组患儿网织红细胞、血清TBi L水平进行对比,分析溶血三项、网织红细胞、血清TBi L,以及上述指标联合检测诊断新生儿溶血病的临床价值。结果140例疑似新生儿溶血病的新生儿患者中确诊患儿100例,非疾病患儿40例,溶血三项检测结果诊断出新生儿溶血病患儿102例,阳性检出率为72.86%,非新生儿溶血病患儿38例(27.14%),新生儿溶血病组患儿网织红细胞(6.99±1.40)%、TBi L(237.21±77.11)μmol/L均比非新生儿溶血病组高(3.47±0.95)%、(170.05±48.65)μmol/L(均P<0.05);溶血三项诊断新生儿溶血病的灵敏度为89.00%(89/100),特异度为67.50%(27/40),阳性预测值和阴性预测值分别为87.25%(89/102)、71.05%(27/38);以5.11%、198.75μmol/L为网织红细胞、TBi L诊断新生儿溶血病的最佳截断值,溶血三项、网织红细胞、血清TBi L及联合检测诊断新生儿溶血病的灵敏度、特异度分别为95.70%、87.56%,均比单项检测的数值高。结论新生儿溶血病患儿网织红细胞、TBi L均比非新生儿溶血病组高,且溶血三项、网织红细胞及血清TBi L联合检测应用于对新生儿溶血病的诊断中,临床应用价值较高。
Objective To explore the clinical diagnostic value of reticulocyte and serum total bilirubin(TBiL)and combined hemolysis in newborns.Methods The clinical data of 140 suspected neonatal patients admitted to Anyang Hospital of Traditional Chinese Medicine from October 2019 to October 2022 were analyzed retrospectively,and all the children were divided into non-neonatal hemolgroup(40 cases)and neonatal group(100 cases).Three items of hemolysis,reticulocytes and serum TBiL were tested in both groups.Analyze the test results of three items of hemolysis,compare the results of hemolysis,compare reticulocyte and serum TBiL levels between neonatal hemolysis group and non-neonatal hemolysis group,analyze the three items of hemolysis,reticulocyte and serum TBiL,and the clinical value of the diagnosis of neonatal hemolysis.Results In 100 confirmed children out of 140 neonatal patients with suspected neonatal hemolysis,40 non-disease children,Three hemolysis tests diagnosed 102 children with neonatal hemolysis disease,The positive detection rate was 72.86%,38(27.14%)children with non-neonatal hemolysis,reticulocytes(6.99±1.40)%and TBiL(237.21±77.11)μmol/L were higher(3.47±0.95)%and(170.05±48.65)μmol/L than the non-neonatal hemolysis group(all P<0.05);The sensitivity of the diagnosis of neonatal hemolysis in the three cases was 89.00%(89/100),Specific to 67.50%(27/40),The positive predictive value and the negative predictive value were 87.25%(89/102)and 71.05%(27/38),respectively;Using 5.11%,198.75μmol/L as the optimal cutoff value for reticulocyte and TBiL,The sensitivity and specificity of hemolysis,reticulocyte,serum TBiL and combined test for the diagnosis of neonatal hemolwere 95.70%and 87.56%,respectively,Both are higher than the single test.Conclusion reticulocyte and TBiL in children with neonatal hemolysis are higher than that of non-neonatal hemolysis group,and the combined test of three hemolysis,reticulocyte and serum TBiL is used in the diagnosis of neonatal hemolysis with high clinical application value.
作者
张前
陈亮
杨冉
ZHANG Qian;CHEN Liang;YANG Ran(Blood transfusion Department of Anyang Hospital of Traditional Chinese Medicine,Anyang 455000,Henan Province,China;Zhengzhou Seventh People's Hospital,Zhengzhou 450016,Henan Province,China;Surgery Department of Anyang Cancer Hospital,Anyang 455000,Henan Province,China)
出处
《罕少疾病杂志》
2024年第2期123-124,127,共3页
Journal of Rare and Uncommon Diseases
基金
河南省医学科技攻关计划项目(LHGJ20210879)。
