摘要
目的观察黄芪竹叶汤配合益气生津片治疗2型糖尿病气阴两虚证的临床效果。方法选取2020年1月—2022年1月期间河南省安阳市中医院收治的2型糖尿病(T2DM)患者90例作为研究对象,按随机数字表法分为对照组和治疗组,每组各45例。两组患者均给予常规西药治疗,对照组采用黄芪竹叶汤,治疗组在对照组基础上加用益气生津丸治疗,均连续治疗3个月。观察比较两组患者临床疗效、不良反应发生率,治疗前后中医证候积分、血糖指标[空腹血糖(Fasting plasma glucose,FPG),糖化血红蛋白(Glycosylated hemoglobin,HbA1c),空腹胰岛素(Fasting insulin,FINS)]及血清炎性因子[C-反应蛋白(C-reactive protein,CRP)、白细胞介素-1β(Interleukin-1β,IL-1β)、白细胞介素-6(Interleukin-6,IL-6)]水平。结果治疗后治疗组总有效率91.11%(41/45)明显高于对照组75.55%(34/45),差异有统计学意义(P<0.05)。治疗后两组患者中医证候积分均较治疗前降低,差异有统计学意义(P<0.05);且治疗组各主症及各次症积分均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血糖指标FPG、FINS、HbA1c均较治疗前降低,差异有统计学意义(P<0.05);且治疗组FPG、FINS、HbA1c均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清炎性因子水平CRP、IL-6、IL-1β均较治疗前降低,差异有统计学意义(P<0.05);且治疗组CRP、IL-6、IL-1β均低于对照组,差异有统计学意义(P<0.05)。治疗期间,两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论黄芪竹叶汤配合益气生津丸是治疗2型糖尿病有效且安全的方案,能明显控制患者血糖,减轻炎症反应。
Objective To observe the clinical effect of Huangqi Zhuye Decoction combined with Yiqi Shengjin Pill in treating type 2 diabetes mellitus with deficiency of Qi and Yin.Methods Ninety patients with type 2 diabetes mellitus(T2DM)treated in Anyang Hospital of TCM in Henan from January 2020 to January 2022 were selected as the research objects,and divided into a control group and a treatment group according to random number table,45 cases in each one.The grouping method was.The conventional Western medicine was used in the two groups.Huangqi Zhuye Decoction was used in the control group,and Yiqi Shengjin Pill was applied in the treatment group on the basis of the control group.All the interventions were continuously for three months.The clinical effect,the incidence of adverse reactions were observed;the Traditional Chinese Medicine(TCM)syndrome score,the blood glucose indices[fasting plasma glucose(FPG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS)]and serum inflammatory factors[C-reactive protein(CRP),interleukin-1β(IL-1β),interleukin-6(IL-6)]before and after treatment were compared.Results After treatment,the total effective rate in the treatment group was 91.11%(41/45),which was significantly higher than 75.55%(34/45)in the control group,with statistical significance(P<0.05).After treatment,the scores of TCM syndromes in both the two groups were lower than those before treatment,and the difference was statistically significant(P 0.05);the scores of the main symptoms and the secondary symptoms in the treatment group were lower than those in the control group,and the difference was statistically significant(P<0.05).After treatment,the blood glucose indices FPG,FINS and HbA1c in the two groups were lower than those before treatment,and the difference was statistically significant(P<0.05).The FPG,FINS and HbA1c in the treatment group were lower than those in the control group,with statistical significance(P<0.05).After treatment,the levels of serum inflammatory factors CRP,IL-6 and IL-1βin the two groups we
作者
张娜
李爽
王琰
庞国明
ZHANG Na;LI Shuang;WANG Yan;PANG Guo-ming(Department of Diabetes Mellitus,Anyang Hospital of TCM,Anyang Henan 455000;Kaifeng Hospital of TCM,Kaifeng Henan 475000)
出处
《世界中西医结合杂志》
2024年第1期156-159,165,共5页
World Journal of Integrated Traditional and Western Medicine
基金
河南省中医药科学研究专项课题(2018ZY3024)。
关键词
黄芪竹叶汤
益气生津片
2型糖尿病
气阴两虚证
Huangqi Zhuye Decoction
Yiqi Shengjin Pills
Type 2 Diabetes Mellitus
Deficiency of Yin and Qi
