摘要
目的 探讨高甘油三酯葡萄糖乘积(TyG)指数与腹膜透析(PD)患者病死率增加是否相关。方法 本研究为单中心、回顾性队列研究。自2007年1月1日至2018年12月31日止,共有519例PD患者被纳入研究。采用了Kaplan-Meier方法和Cox回归模型,对TyG指数水平与PD患者全因死亡率和CVD死亡率之间的相关性进行分析。结果 本研究中位随访时间为35.4(8,101)月,有104例(20.0%)PD患者在研究结束时死亡,其中55例(52.9%)死于心血管疾病(CVD)。基线时中位血清TyG指数为8.44(6.48,11.94)。在Cox回归分析中,对患者的性别、年龄、BMI、有无CVD、高血压等因素进行调整,发现高TyG指数组全因死亡的风险显著升高(HR=2.22,95%CI:1.43~3.44,P <0.001),同时CVD死亡风险也有所上升(HR=2.50,95%CI:1.34~4.65,P=0.004)。此外,对于高时间平均的TyG指数(TA-TyG指数)而言,它同样与全因死亡和CVD死亡风险呈现出了相似的关系(分别为HR=1.90,95%CI:1.25~2.90,P=0.003和HR=2.05,95%CI:1.14~3.70,P=0.017)。结论 高TyG指数的PD患者出现全因死亡和CVD死亡的风险较高。
Objective The objective of this study is to investigate whether there is a correlation between a high TyG index(serum triglyceride glucose index)and higher mortality rates among patients undergoing peritoneal dialysis(PD).Methods This study utilized a single-center retrospective cohort as the basis for its methods..From January 1,2007 to December 31,2015,a total of 519 PD patients kept under observation until December 31,2018.There searchers employed the Kaplan-Meier method and Cox proportional hazards modelsto examine the cor⁃relation between TyG index levels and mortality.Results Over a period of 40.5 months,104(20.0%)individuals with Parkinson's disease passed away,with 55(52.9%)of these deaths attributed to cardiovascular disease(CVD).The serum median TyG index at baseline was 8.44(6.48,11.94).Through Cox regression analysis subject to the adjustments of such parameters as gender,age,body mass index(BMI),presence of cardiovascular disease,hypertension,diabetes mellitus,hemoglobin,serum albumin,serum Ferritin,total cholesterol,renal residual function(RRF),An increased risk of all-cause mortality(HR=2.22,95%CI:1.43~3.44,P<0.001)and CVD mortality(HR=2.50,95%CI:1.34~4.65,P=0.004)was observed with a higher baseline TyG index(8.44).A comparable impact was observed in the correlation between the average TyG index over time(TA-TyG index)and both all-cause mortality and CVD mortality.(HR=1.90,95%CI:1.25~2.90,P=0.003;HR=2.05,95%CI:1.14~3.70,P=0.017,respectively).Conclusion PD patients with a higher serum TyG index have a greater risk of all-cause mortality and mortality related to cardiovascular disease.
作者
杨珊
李红英
周静璇
陈耀德
李亚琴
古梓棋
牛红心
YANG Shan;LI Hongying;ZHOU Jingxuan;CHEN Yaode;LI Yaqin;GU Ziqi;NIU Hongxin(Department of General Practice,Zhujiang Hospital,Southern Medical University,Guangzhou 510220,China;Longfeng Street Community Health Service Center,Haizhu District,Guangzhou 510250,China;Special Medical Service Center,ZhujiangHospital,Southern Medical University,Guangzhou 510220,China;不详)
出处
《实用医学杂志》
CAS
北大核心
2024年第3期371-377,共7页
The Journal of Practical Medicine
基金
广州市基础与应用基础研究一般项目(编号:02102080020)
广东省基础与应用基础研究基金面上项目(编号:2021A1515010728)。
