摘要
目的 探讨血清富亮氨酸α-2糖蛋白-1(leucine-rich α2-glycoprotein-1,LRG1)水平与维持性血液透析患者动脉粥样硬化程度的关系。方法 选取2016年1月至2020年1月在秦皇岛市第一医院进行血液透析的160例维持性血液透析患者作为研究对象,收集其一般资料及实验室指标。采用彩色多普勒超声测定患者颈动脉内中膜厚度(intima-media thickness,IMT),并将其分为正常组55例,其中男28例,女27例,年龄(50.26±7.94)岁,年龄范围40~80岁;内膜增厚组58例,其中男30例,女28例,年龄(60.72±8.63)岁,年龄范围41~80岁;斑块组47例,其中男26例,女21例,年龄(70.14±8.28)岁,年龄范围40~80岁。采用酶联免疫吸附法检测患者血清LRG1水平。采用Pearson及Spearman相关性分析维持性血液透析患者IMT与一般资料、实验室指标及血清LRG1的相关性;采用多因素Logistic回归分析维持性血液透析患者动脉粥样硬化的影响因素。结果 斑块组LRG1为(83.74±9.94)mg/L,年龄为(70.14±8.28)岁,透析龄为(38.72±6.49)个月,低密度脂蛋白胆固醇(low density lipoprotein-cholesterol,LDL-C)为(2.52±0.61)mmol/L,总胆固醇(total cholesterol,TC)为(4.21±1.02)mmol/L,均显著高于内膜增厚组的(67.95±8.65)mg/L、(60.72±8.63)岁、(33.48±6.50)个月、(1.89±0.59)mmol/L、(3.52±0.78)mmol/L和正常组的(52.46±8.73)mg/L、(50.26±7.94)岁、(29.72±6.78)个月、(1.42±0.62)mmol/L、(2.96±0.81)mmol/L,各组差异均有统计学意义(P<0.05)。维持性血液透析患者IMT与LRG1、年龄、透析时间、LDL-C、TC均呈正相关(r=0.534、0.509、0.512、0.492、0.489,P<0.05)。LRG1、年龄是维持性血液透析患者动脉粥样硬化的独立危险因素(P<0.05)。结论 随着维持性血液透析患者动脉粥样硬化程度增加,血清LRG1水平升高,且LRG1与IMT呈正相关,提示检测血清LRG1水平有助于评估颈动脉粥样硬化程度。
Objective To explore the relationship between serum level of leucine-richα2-glyco-protein-1(LRG1)and the degree of atherosclerosis in maintenance hemodialysis(MHD)patients.Methods From January 2016 to January 2020,160 MHD patients were selected as research subjects and their general profiles and laboratory parameters recorded.Intima-media thickness(IMT)of carotid artery was measured by color Doppler ultrasonography.They were assigned into three groups of normal(n=55),endometrial thickening(n=58)and plaque(n=47).Normal group was composed of 28 males and 27 fe-males with an average age of(50.26±7.94)(40-80)year;Endometrial thickening group had 30 males and 28 females with an average age of(60.72±8.63)(41-80)year;Plaque group included 26 males and 21 fe-males with an average age of(70.14±8.28)(40-80)year.Enzyme-linked immunosorbent assay(ELISA)was utilized for measuring the serum level of LRG1.Pearson/Spearman’s correlation was employed for analyzing the correlation between IMT and general profiles,laboratory parameters and serum level of LRG1;multivariate logistic regression was performed for examining the influencing factors of atherosclerosis in MHD patients.Results When comparing plaque,endometrial thickening and normal groups,LRG1 was[(83.74±9.94)vs(67.95±8.65)vs(52.46±8.73)mg/L],age[(70.14±8.28)vs(60.72±8.63)vs(50.26±7.94)years],dialysis time[(38.72±6.49)vs(33.48±6.50)vs(29.72±6.78)month],low-density lipoprotein cholesterol(LDL-C)[(2.52±0.61)vs(1.89±0.59)vs(1.42±0.62)mmol/L]and total cholesterol(TC)[(4.21±1.02)vs(3.52±0.78)vs(2.96±0.81)mmol/L.All were significantly higher in plaque group than those in endometrial thickening and normal groups.And the differences between each group were statistically significant(P<0.05).IMT was correlated positively with LRG1,age,dialysis time,LDL-C and TC(r=0.534,0.509,0.512,0.492,0.489,P<0.05).And LRG1 and age were independent risk factors for atherosclerosis in MHD patients(P<0.05).Conclusion With advancing degree of atherosclerosis,serum level of LRG1 ri
作者
张健美
方倩
顾铜
刘洋
李亚光
李慧妍
Zhang Jian-mei;Fang Qian;Gu Tong;Liu Yang;Li Ya-guang;Li Hui-yan(Hemodialysis Room,First Hospital of Qinhuangdao,Qinhuangdao 066000,China)
出处
《临床肾脏病杂志》
2023年第9期739-743,共5页
Journal Of Clinical Nephrology
基金
秦皇岛市科学技术研究与发展计划(202004A101)。
