摘要
目的探究先兆流产患者联合应用地屈孕酮、黄体酮治疗对保胎成功情况、激素水平、新生儿出生指标、疗效及安全性的影响。方法100例先兆流产患者,经随机数字表法分为对照组与观察组,每组50例。对照组实施地屈孕酮治疗,观察组实施地屈孕酮联合黄体酮治疗。比较两组保胎成功情况、激素[雌二醇(E_(2))、孕酮(P)、人绒毛膜促性腺激素(HCG)]水平、新生儿指标(新生儿体重和新生儿畸形率)、治疗效果以及不良反应发生情况。结果观察组保胎成功率为88.00%,高于对照组的70.00%,差异显著(P<0.05)。治疗后,两组E_(2)、P、HCG水平均上升,且观察组E_(2)、P、HCG水平分别为(1078.41±18.26)pg/ml、(31.86±3.66)nmol/L、(8574.21±96.69)U/ml,高于对照组的(905.25±26.69)pg/ml、(25.91±4.13)nmol/L、(7410.33±105.53)U/ml,差异显著(P<0.05)。对照组新生儿体重为(3259.87±84.91)g,新生儿畸形0例;观察组新生儿体重为(3275.46±86.29)g,新生儿畸形1例(2.00%)。两组新生儿体重、新生儿畸形率比较无显著差异(P>0.05)。观察组治疗总有效率96.00%高于对照组的84.00%,差异显著(P<0.05)。两组不良反应发生率比较,无显著差异(P>0.05)。结论先兆流产患者联合应用地屈孕酮、黄体酮治疗可获得突出效果,利于提升先兆流产保胎成功率,改善激素水平,不会对新生儿出生指标产生影响,且安全性较高,建议临床推广应用。
Objective To explore the effect of dydrogesterone combined with progesterone on the success of fetal preservation,hormone level,neonatal birth index and curative effect and safety of threatened abortion.Methods A total of 100 patients with threatened abortion were divided into a control group and an observation group by random number table,with 50 cases in each group.The control group was treated with dydrogesterone,and the observation group was treated with dydrogesterone and progesterone.The success of fetal preservation,hormone[estradiol(E_(2)),progesterone(P),human chorionic gonadotropin(HCG)]level,neonatal index(neonatal weight,neonatal malformation rate),the treatment effect and the occurrence of adverse reactions were compared between the two groups.Results The success rates of fetal preservation in the observation group was 88.00%,which was higher than 70.00%in the control group,with a significant difference(P<0.05).After treatment,the E_(2),P and HCG levels increased in both groups,and E_(2),P and HCG levels in the observation group were(1078.41±18.26)pg/ml,(31.86±3.66)nmol/L and(8574.21±96.69)U/ml,which were higher than(905.25±26.69)pg/ml,(25.91±4.13)nmol/L and(7410.33±105.53)U/ml in the control group.The difference was significant(P<0.05).The neonatal weight in the control group was(3259.87±84.91)g,with 0 case of neonatal malformations;the neonatal weight in the observation group was(3275.46±86.29)g,with 1 case(2.00%)of neonatal malformation.There was no significant difference in neonatal weight and neonatal malformation rate between the two groups(P>0.05).The total effective rate of 96.00%in the observation group was higher than 84.00%in the control group,with a significant difference(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of dydrogesterone and progesterone in the treatment of threatened abortion patients can achieve prominent effect,which is beneficial to improve the success rate of fetal pres
作者
杜鲁豫
陈怀博
DU Lu-yu;CHEN Huai-bo(Department of Obstetrics and Gynecology,Liaocheng Maternal and Child Health Hospital,Liaocheng 252000,China)
出处
《中国实用医药》
2024年第3期33-36,共4页
China Practical Medicine
关键词
地屈孕酮
黄体酮
先兆流产
保胎成功情况
激素水平
新生儿出生指标
Dydrogesterone
Progesterone
Threatened abortion
Success of fetal preservation
Hormone level
Neonatal birth index
