摘要
目的分析长沙县上呼吸道感染病原谱特点,探讨该地区常见呼吸道病原体的共感染分布特征,为该地区呼吸道感染疾病的早期诊断和治疗提供可靠依据。方法回顾性分析湖南省长沙市长沙县妇幼保健院门急诊于2022年1—6月收治的17456例上呼吸道感染患儿(年龄<14岁)的临床资料,患儿均采集咽拭子标本,采用多重聚合酶链反应检测6种常见病原体:甲型流感病毒(Flu.A)、乙型流感病毒(Flu.B)、呼吸道合胞病毒(RSV)、腺病毒(ADV)、鼻病毒(HRV)、肺炎支原体(MP),分析不同性别、年龄患儿病原体检出情况,以及单一感染率与混合感染率等感染分布特征。结果17456例患儿病原体检出率为52.93%,主要感染病原体依次为Flu.B(24.00%)、HRV(11.41%)、Flu.A(8.41%)、RSV(6.54%)、ADV(5.20%)和MP(1.45%),混合感染率为4.02%。男童中MP与Flu.B或ADV混合感染率高于女童,差异有统计学意义(P<0.05)。随着年龄增长,Flu.B及MP检出率明显升高,差异有统计学意义(P<0.05)。MP、ADV感染患儿更易发生混合感染,MP混合感染约占MP总感染的24.11%,MP混合感染患儿白细胞计数异常、中性粒细胞百分比异常、淋巴细胞百分比异常的比例相对MP单一感染患儿更高,差异有统计学意义(P<0.05)。结论该地区儿童常见上呼吸道感染病原体主要为Flu.B、HRV、Flu.A,常见病原体检出率及其混合感染率呈现年龄差异性,MP感染患儿易发生混合感染,及时、准确鉴别呼吸道感染病原体有利于早期诊断和合理用药。
Objective To analyze the characteristics of the pathogen spectrum of upper respiratory tract infection in Changsha County,to explore the co-infection distribution characteristics of common respiratory pathogens in this area,and to provide reliable basis for the early diagnosis and treatment of respiratory tract infection in this area.Methods The clinical data of 17456 children(<14 years old)with upper respiratory tract infection admitted to the outpatient and Department of Emergency in Maternal and Child Health Care Hospital of Changsha County from January to June 2022 were selected as the research objects.Throat swabs were collected from the patients,and multiplex polymerase chain reaction was used to detect six common pathogens including influenza A virus(Flu.A),influenza B virus(Flu.B),respiratory syncytial virus(RSV),adenovirus(ADV),rhinovirus(HRV)and mycoplasma pneumoniae(MP),the distribution characteristics of children with different gender and age,single infection and mixed infection were analyzed.Results The pathogen detection rate of 17456 children was 52.93%.Flu.B(24.00%),HRV(11.41%),Flu.A(8.41%),RSV(6.54%),ADV(5.20%)and MP(1.45%)were the most common pathogens,and the mixed infection rate was 4.02%.The co-infection rates of MP and Flu.B or ADV in boys were significantly higher than those in girls(P<0.05).The detection rates of Flu.B and MP increased significantly with age(P<0.05).Children with MP,ADV infection were more likely to have mixed infection,and MP mixed infection accounted for about 24.11%of the total MP infection.The children with MP mixed infection had higher proportions of abnormal white blood cell count,abnormal percentage of neutrophils and abnormal percentage of lymphocytes than those with MP single infection,the differences were statistically significant(P<0.05).Conclusion Flu.B,HRV and Flu.A are the most common pathogens in children with upper respiratory tract infection in this area.The infection of each common pathogen and its mixed infection are different in age,especially in childr
作者
彭杜平
洪迎瑞
喻娟娟
范英杰
李兴军
王群
周凡琦
杨牡丹
李敏
PENG Duping;HONG Yingrui;YU Juanjuan;FAN Yingjie;LI Xingjun;WANG Qun;ZHOU Fanqi;YANG Mudan;LI Min(Department of Pediatrics,Maternal and Child Health Care Hospital of Changsha County,Changsha,Hunan 410100,China;Department of Clinical Laboratory,Maternal and Child Health Care Hospital of Changsha County,Changsha,Hunan 410100,China;National-Local Joint Engineering Research Center for Genetic Diagnosis of Infectious Diseases and Tumors,Changsha,Hunan 410000,China)
出处
《检验医学与临床》
2024年第4期524-529,共6页
Laboratory Medicine and Clinic
关键词
上呼吸道
病原体
共感染
儿童
肺炎支原体
甲型流感病毒
乙型流感病毒
呼吸道合胞病毒
upper respiratory tract
pathogens
co-infection
children
mycoplasma pneumoniae
influenza A virus
influenza B virus
respiratory syncytial virus
