摘要
目的探讨双歧杆菌活菌胶囊分别与英夫利西单抗、美沙拉嗪联合治疗溃疡性结肠炎(UC)的效果及对患者肠道菌群、UC内镜严重程度指数(UCEIS)评分的影响。方法选取2018年1月至2022年12月在西安国际医学中心医院就诊的82例UC患者作为研究对象,按随机数表法分为观察组和对照组各41例。两组患者均给予双歧杆菌活菌胶囊治疗,观察组在此基础上给予英夫利西单抗治疗,对照组则给予美沙拉嗪肠溶片治疗,两组患者均治疗6周。比较两组患者的临床疗效、临床症状缓解时间、住院时间,以及治疗前后的超敏C反应蛋白(hs-CRP)、白介素(IL-4、IL-8、IL-6)、肠道菌群和UCEIS评分,同时比较两组患者治疗期间的不良反应发生情况。结果观察组患者的治疗总有效率为97.56%,明显高于对照组的85.37%,差异有统计学意义(P<0.05);观察组患者的腹痛时间、腹泻时间、便血时间和住院时间分别为(8.56±1.53)d、(8.69±1.47)d、(8.77±1.65)d、(12.36±2.91)d,明显短于对照组的(12.05±1.38)d、(12.33±1.29)d、(12.74±1.46)d、(17.88±3.06)d,差异均有统计学意义(P<0.05);治疗后,两组患者的结肠黏膜炎症程度较治疗前减轻,差异均有统计学意义(P<0.05),但两组患者治疗后组间比较差异均无统计学意义(P>0.05);治疗后,两组患者的双歧杆菌、大肠杆菌、乳酸杆菌较治疗前升高,肠球菌较治疗前降低,差异均有统计学意义(P<0.05),但两组患者治疗后组间比较差异均无统计学意义(P>0.05);治疗后,两组患者的hs-CRP、IL-8、IL-6水平较治疗前降低,IL-4水平较治疗前升高,且观察组治疗后的hs-CRP、IL-8、IL-6水平分别为(4.15±2.56)mg/L、(45.75±10.81)ng/L、(40.39±4.30)pg/mL,明显低于对照组的(5.82±2.91)mg/L、(52.11±11.03)ng/L、(46.48±4.43)pg/mL,观察组治疗后的IL-4水平为(26.18±2.25)pg/mL,明显高于对照组的(22.37±2.58)pg/mL,差异均有统计学意义(P<0.05);治疗期间,观察组患者�
Objective To explore the curative effect of infliximab and mesalazine combined with live Bifidobacterium capsule in patients with ulcerative colitis(UC)and their influences on intestinal floras and score of Ulcerative Colitis Endoscopic Index of Severity(UCEIS).Methods A total of 82 patients with UC treated in Xi'an International Medical Center Hospital were enrolled as the research objects between January 2018 and December 2022.According to random number table method,they were divided into an observation group(41 cases)and a control group(41 cases).On basis of live Bifidobacterium capsules,patients in the observation group were given infliximab,while those in the control group were given mesalazine enteric-coated tablets.All patients were treated for 6 weeks.The clinical curative effect,remission time of clinical symptoms,length of hospital stay,levels of hypersensitive C-reactive protein(hs-CRP),and interleukins(IL-4,IL-8,IL-6),intestinal floras,and UCEIS scores before and after treatment,and the occurrence of adverse reactions during treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was 97.56%,significantly higher than 85.37% in the control group(P<0.05).The duration of abdominal pain,diarrhea,rectal bleeding,and length of hospital stay in the observation group were(8.56±1.53)d,(8.69±1.47)d,(8.77±1.65)d,and(12.36±2.91)d,respectively,which were significantly shorter than(12.05±1.38)d,(12.33±1.29)d,(12.74±1.46)d,and(17.88±3.06)d in the control group(P<0.05).After treatment,the degree of colonic mucosal inflammation in the two groups of patients decreased significantly compared to that before treatment(P<0.05),but there was no statistically significant difference between the two groups of patients after treatment(P>0.05).After treatment,the levels of Bifidobacterium,Escherichia coli,and Lactobacillus in the two groups of patients increased significantly compared to those before treatment,while the levels of Enterococcus decreased signific
作者
秦士钊
胡冠鑫
杜晨艳
崔艳莉
QIN Shi-zhao;HU Guan-xin;DU Chen-yan;CUI Yan-li(Department of Gastroenterology,Xi'an International Medical Center Hospital,Xi'an 710100,Shaanxi,CHINA;Gastrointestinal Endoscopy Center,Xi'an International Medical Center Hospital,Xi'an 710100,Shaanxi,CHINA)
出处
《海南医学》
CAS
2024年第3期329-333,共5页
Hainan Medical Journal
基金
陕西省重点研发计划项目(编号:S2020-YF-YBSF-0777)。
