摘要
目的:观察益肾平肝方对H型高血压及其早期肾损害的作用效果,为益肾平肝方防治H型高血压及其肾损害走向提供临床依据。方法:收集2014年3月至2015年2月上海中医药大学附属普陀医院中医科接诊的H型高血压早期肾损害患者67例,随机数字表法分为两组,西药组34例,中西药组33例。西药组给予氯沙坦钾+叶酸治疗,中西药组给予益肾平肝方+氯沙坦钾+叶酸治疗,两组患者分别干预3个月后,采用中医症状量表观察两组患者的症状变化,采用24 h动态血压测定法测量患者的的24 h动态血压变化,采用酶联免疫吸附试验法测患者血清同型半胱氨酸(Hcy)、尿微量白蛋白(mAlb)、尿β2–微球蛋白(β2–MG)的变化。结果:治疗后,中西药组患者临床总有效率为87.9%,明显高于西药组的76.5%,差异具有统计学意义(P <0.05)。治疗后,两组患者的24 h平均收缩压、24 h平均舒张压、尿m Alb、尿β2–MG、血清Hcy均显著降低,差异具有统计学意义(P <0.01)。且中西药组患者的症状改善更为明显,24 h平均收缩压、24 h平均舒张压、血清Hcy、尿mAlb及β2–MG水平均低于西药组,差异均具有统计学意义(P <0.05)。结论:益肾平肝方联合氯沙坦钾、叶酸疗法可改善H型高血压患者的症状、降低血压、血清Hcy水平,有早期肾脏保护作用。
Objective To observe the effects of Yishen Pinggan recipe on early renal damage caused by H-type hypertension,providing clinical basis for the prevention and treatment of H-type hypertension and its renal damage with Yishen Pinggan recipe.Methods A total of 67 patients with early renal damage caused by H-type hypertension admitted to the Department of Traditional Chinese Medicine,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from March 2014 to February 2015 were collected and divided into two groups by random number table method:34 patients in the western medicine group and 33 patients in the Chinese-Western medicine group.The western medicine group was given losartan potassium + folic acid treatment,and the Chinese-Western medicine group was given Yishenpinggan Recipe + losartan potassium +folic acid treatment.After 3 months of intervention,the symptom changes of the two groups of patients were observed by the traditional Chinese Medicine(TCM) symptom scale,and the 24 h ambulatory blood pressure was measured by 24 h ambulatory blood pressure measurement.Serum homocysteine(Hcy),urinary microalbumin(mAlb) and urinary β2-microglobulin(β2-mg)were measured by enzyme-linked immunosorbent assay.Results After treatment,the total clinical effective rate in the ChineseWestern medicine group was 87.9 %,which was significantly higher than 76.5 % of the Western medicine group,and the difference was statistically significant(P < 0.05).After treatment,the 24 h mean systolic blood pressure,24 h mean diastolic blood pressure,the levels of urinary mAlb,urinary β2-MG and serum Hcy were significantly decreased in two groups,and the differences were statistically significant(P < 0.01).Moreover,the improvement of symptoms was more obvious in the Chinese-Western medicine group,and the 24 h mean systolic blood pressure,24 h mean diastolic blood pressure,the levels of serum Hcy,urinary mAlb and β2-MG were lower than those in the western medicine group,and the differences were statistically signific
作者
罗国东
刘龙民
LUO Guodong;LIU Longmin(Guangdong Provincial Cadre Health Care Center,Guangdong Guangzhou 510030;Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062;Zhabei Central Hospital,Jing'an District,Shanghai,200070)
出处
《深圳中西医结合杂志》
2023年第21期35-38,共4页
Shenzhen Journal of Integrated Traditional Chinese and Western Medicine
基金
上海中医药大学附属普陀医院重点专科项目(2013XK156I)。
关键词
H型高血压
早期肾损害
益肾平肝方
H-type hypertension
Early-stage renal damage
Yishen Pinggan recipe
