摘要
目的:探讨丹参对静脉留置导管相关纤维蛋白鞘的作用。方法:选用120只兔随机分为模型组、丹参组、低分子肝素钙组。模型组、丹参组、低分子肝素钙组分别随机均分5个留置时相亚组。模型组静脉滴注甘露醇;丹参组静脉滴注甘露醇,加肌内注射丹参注射液;低分子肝素钙组静脉滴注甘露醇,加皮下注射低分子肝素钙。各组均记录滴注单位甘露醇所需时间、导管发生纤维蛋白鞘机械活瓣次数、D⁃二聚体(D⁃D)浓度。结果:丹参组和低分子肝素钙组滴注单位甘露醇所需时间、发生纤维蛋白鞘机械活瓣次数、D⁃D浓度均明显低于模型组,差异具有统计学意义(P<0.05)。而丹参组与低分子肝素钙组比较,差异无统计学意义(P>0.05)。结论:丹参对导管相关纤维蛋白鞘具有一定干预效果。
Objective:To explore the effect of Danshen on the fibrin sheath associated with venous indwelling catheter.Methods:120 rabbits were then randomly divided into the model group,Danshen group,and low molecular weight heparin calcium group.The model group,Danshen group,and low molecular weight heparin calcium group were then randomly divided into 5 retention phase subgroups.The model group were received intravenous drip of mannitol while the Danshen group were received intravenous drip of mannitol and intramuscular injection of Danshen injection,and the low molecular weight heparin calcium group were received intravenous drip of mannitol and subcutaneous injection of low molecular weight heparin calcium.The time required,the number of mechanical valve phenomena related to the catheter related fibrin sheath and the D⁃dimer concentration of all the groups were recorded.Results:As a result,the time required for completing a unit of mannitol infusion,the frequency of mechanical valve phenomenon with fibrin sheath,and the concentration of D⁃dimer in the Danshen group and low molecular weight heparin calcium group were significantly lower than those in the model group,and the difference was statistically significant(P<0.05).However,there was no statistically significant difference between the Danshen group and the low molecular weight heparin calcium group(P>0.05).Conclusion:Danshen has a certain intervention effect on the catheter related with the fibrin sheath.
作者
唐文帅
喻爱芳
廖维甲
覃海敏
刘春英
韦义萍
TANG Wenshuai;YU Aifang;LIAO Weijia;QIN Haimin;LIU Chunying;WEI Yiping(College of Nursing,Guilin Medical University,Guilin 541004;Liuzhou People′s Hospital,Liuzhou 545006;College of Nursing,Guangxi Medical University,Nanning 530021,China)
出处
《华夏医学》
CAS
2023年第5期54-59,共6页
Acta Medicinae Sinica
基金
广西高校中青年教师科研基础能力提升项目(2020KY12035)
国家自然科学基金项目(81260290)。
关键词
丹参
静脉留置导管
纤维蛋白鞘
干预效果
Danshen
venous indwelling catheter
fibrin sheath
intervention effect
