摘要
目的:观察丹参注射液联合阿司匹林肠溶片、替格瑞洛片治疗急性ST段抬高型心肌梗死(STEMI)经皮冠状动脉介入术(PCI)后患者的效果。方法:选取2022年10月至2023年4月该院收治的80例STEMI PCI术后患者进行前瞻性研究,按照随机数字表法将其分为研究组与对照组各40例。对照组采用阿司匹林肠溶片联合替格瑞洛片治疗,研究组在对照组基础上加用丹参注射液治疗,比较两组临床疗效、心功能指标[左心室射血分数(LVEF)、左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)]水平、血清C反应蛋白(CRP)水平、血清氨基末端脑钠肽前体(NT-proBNP)水平和肾功能指标[血肌酐、血清胱抑素C、肾小球滤过率]水平。结果:研究组治疗总有效率为92.50%,明显高于对照组的72.50%,差异有统计学意义(P<0.05);治疗后,研究组LVEF水平和肾小球滤过率高于对照组,LVEDD、LVESD、CRP、NT-proBNP、血肌酐、血清胱抑素C水平低于对照组,差异均有统计学意义(P<0.05)。结论:丹参注射液联合阿司匹林肠溶片、替格瑞洛片治疗STEMI PCI术后患者可提高治疗总有效率,改善心功能指标和肾功能指标水平,降低血清CRP、NT-proBNP水平,效果优于阿司匹林肠溶片联合替格瑞洛片治疗。
Objective:To observe effects of Danshen injection combined with Aspirin enteric-coated tablets and Ticagrelor tablets on patients with acute ST-segment elevation myocardial infarction(STEMI)after percutaneous coronary intervention(PCI).Methods:A prospective study was conducted on 80 patients with STEMI after PCI admitted to this hospital from October 2022 to April 2023.They were divided into study group and control group according to the random number table method,40 cases in each group.The control group was treated with Aspirin entericcoated tablets combined with Ticagrelor tablets,while the study group was treated with Danshen injection on the basis of that of the control group.The clinical effects,the cardiac function indexes[left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD),left ventricular end-systolic diameter(LVESD)]levels,serum C-reactive protein(CRP)levels,serum N-terminal pro-brain natriuretic peptide(NT-proBNP)levels,and the renal function indexes[serum creatinine,serum cystatin C,glomerular filtration rate]levels were compared between the two groups.Results:The total effective rate of treatment in the study group was 92.50%,which was significantly higher than 72.50%in the control group,the difference was statistically significant(P<0.05).After the treatment,the levels of LVEF and glomerular filtration rate in the study group were higher than those in the control group,the levels of LVEDD,LVESD,CRP,NT-proBNP,serum creatinine and cystatin C were lower than those in the control group,and the differences were statistically significant(P<0.05).Conclusions:Danshen injection combined with Aspirin enteric-coated tablets and Ticagrelor tablets for the STEMI patients after PCI can improve the total effective rate of treatment,improve the levels of cardiac function indexes and renal function indexes,and reduce the levels of serum CRP and NT-proBNP.Moreover,it is superior to Aspirin enteric-coated tablets combined with Ticagrelor tablets treatment.
作者
孟亚锋
张亚楠
MENG Yafeng;ZHANG Yanan(Department of Cardiology of Kaifeng Central Hospital,Kaifeng 475000 Henan,China)
出处
《中国民康医学》
2024年第2期81-83,共3页
Medical Journal of Chinese People’s Health
关键词
经皮冠状动脉介入治疗
术后
急性ST段抬高型心肌梗死
丹参注射液
心功能
肾功能
C反应蛋白
Percutaneous coronary intervention
Postoperative
Acute ST-segment elevation myocardial infarction
Danshen injection
Cardiac function
Renal function
C-reactive protein
