摘要
目的:探讨某高校教职工非酒精性脂肪肝(nonalcoholic fatty liver diseases,NAFLD)患病与年龄相关性的性别差异及危险因素。方法:选取北京某高校2019年参加体检的3003名教职工作为研究对象,采用广义线性模型探索不同性别人群年龄与NAFLD发生率之间的线性或非线性关系,采用多因素logistic回归模型分析各组人群NAFLD与BMI分组、血脂异常、糖尿病、高血压、肝功能异常、血尿酸升高和高敏C反应蛋白的关系。结果:男性和女性教职工NAFLD检出率分别为45.54%和25.59%,NAFLD最高患病风险年龄点分别为51.00岁和60.36岁。对于<51.00岁的男性教职工,BMI分组、血脂异常、肝功能异常是NAFLD患病的独立危险因素,差异有统计学意义(P<0.05);对于≥51.00岁的男性教职工,年龄、BMI分组、血脂异常、糖尿病和血尿酸升高是NAFLD患病的独立危险因素,差异有统计学意义(P<0.05)。对于<60.36岁的女性教职工,除高敏C反应蛋白之外,其他变量均为NAFLD患病的独立危险因素;对于≥60.36岁的女性教职工,糖尿病和高血压不是NAFLD患病的独立危险因素。结论:高校教职工NAFLD患病率及危险因素存在年龄及性别差异,应根据不同性别和年龄段,对NAFLD患者采取针对性的治疗措施。
OBJECTIVE To explore the gender difference of association between nonalcoholic fatty liver diseases(NAFLD)and age and influencing factors among college staff.METHODS 3003 college staff of a university in Beijing who participated in physical examination in 2019 were selected as the subjects of study.Generalized additive models(GLM)were used to explore the linear or non⁃linear relationship between age and NAFLD of different sex groups,multivariate logistic regression was used to further analyze the re⁃lationship between NAFLD and the influencing factors of excessive BMI,dyslipidemia,diabetes,hypertension,abnormal liver func⁃tion,hyperuricemia and high sensitivity C-reactive protein in each group.RESULTS 45.54%of male and 25.59%of female college staff were detected with NAFLD and the highest risk age of NAFLD was 51.00 and 60.36 years old,respectively.Excessive BMI,dys⁃lipidemia and abnormal liver function were independent influencing factors for NAFLD among male under 51.00 and excessive BMI,dyslipidemia,diabetes and hyperuricemia were independent influencing factors of NAFLD among male aged 51.00 or over(P<0.05).Other factors were independent influencing factors for NAFLD except for high-sensitivity C-reactive protein among female under 60.36 and diabetes and hypertension were no longer independent influencing factors for NAFLD among female aged 60.36 or over(P<0.05).CONCLUSION There were age and gender difference of the prevalence rate and influencing factors of NAFLD among uni⁃versity college staff.
作者
刘玲
马文军
Liu Ling;Ma Wenjun(Beijing Forestry University Hospital,Beijing,100083,China)
出处
《中国初级卫生保健》
2024年第1期50-53,共4页
Chinese Primary Health Care
关键词
高校教职工
NAFLD
年龄
性别
危险因素
college staff
nonalcoholic fatty liver diseases(NAFLD)
age
gender
influencing factors
