摘要
硼中子俘获疗法(BNCT)是一种基于10B(n,α)7Li反应治疗肿瘤的方法,硼(10B)化合物携带剂进入人体后选择性富集于肿瘤细胞内,与外照射中子发生反应,由于产生的7Li(4 μm)和α粒子(7 μm)会沉积在一个细胞量级(10 μm),因此可以达到定向局域性杀死肿瘤细胞且对正常组织伤害较小的目的。迄今为止,BNCT已经在多种肿瘤进行了临床研究,包括多形性胶质母细胞瘤、脑膜瘤、头颈部肿瘤、肺癌等。本文主要介绍BNCT治疗头颈部肿瘤的临床研究进展。
Boron neutron capture therapy is a method based on 10B(n,α)7Li reaction to achieve malignancy treatment.Upon entry into the human body,the 10B compound carrier can selectively enriched in tumor cells and reacts with external irradiation neutrons.Because 7Li(4μm)andαparticles(7μm)will be deposited in a cell magnitude(10μm),the purpose of directional local killing of tumor cells and causing less harm to normal tissue can be achieved successfully.So far,boron neutron capture therapy has been clinically studied in a variety of malignant diseases,including glioblastoma multiforme,meningeoma,head and neck cancer,lung cancer,etc.In this article,the clinical research progress of boron neutron capture treatment in head and neck carcinomas was mainly introduced.
作者
伍艳萍
罗凤霞
李月敏
Wu Yanping;Luo Fengxia;Li Yuemin(Department of Radiotherapy,the Eighth Medical Center PLA General Hospital,Beijing 100091,China)
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2024年第1期62-66,共5页
Chinese Journal of Radiation Oncology
关键词
头颈部肿瘤
硼中子俘获疗法
临床试验
Head and neck neoplasms
Boron neutron capture therapy
Clinical trials
