摘要
硼中子俘获疗法(Boron Neutron Capture Therapy,BNCT)是当前治疗脑胶质瘤等恶性肿瘤的唯一有效方法,而对恶性肿瘤有高特异性的含硼药物的制备是硼中子捕获治疗研究中的一个重点。用已知BNCT药物BPA接枝mPEG-壳聚糖,进一步提高BPA的水溶性及肿瘤对硼药物的摄取率,以期达到BNCT药物的要求。目标产物通过红外,核磁表征表明聚乙二醇和BPA都成功的链接到壳聚糖上,所制得的产物有望成为潜在的BNCT药物。
Boron neutron capture therapy （BNCT） is a binary anti-cancer therapy,It is important to improve the boron delivery vehicles to maximize the tumor / healthy tissue ratio for BNCT. The aim of this study was to design and synthesis BPA grafted mPEC-chitosan in order to improve the solubility of BPA and tumor uptake of drugs as potential boron carrier for BNCT. The successful grafting were proved by FTIR and MRI.
出处
《化工新型材料》
CAS
CSCD
北大核心
2014年第8期151-153,共3页
New Chemical Materials
基金
中国工程物理研究院核物理与化学研究所科技创新基金(2011QP03)
