摘要
目的探讨结肠癌患者外周血CD4^(+)、CD8^(+)细胞、程序性死亡因子-1(PD-1)表达水平及其临床意义。方法选择2022年8月至2023年8月杭州市肿瘤医院与浙江大学医学院附属浙江医院收治的78例结肠癌患者作为观察组,并选择同期杭州市肿瘤医院与浙江大学医学院附属浙江医院接受体检的70例健康人员作为对照组。比较两组受试者外周血CD4^(+)、CD8^(+)细胞、PD-1水平,比较观察组不同病理特征患者的外周血CD4^(+)、CD8^(+)细胞、PD-1水平,采用Pearson相关性分析法分析外周血CD4^(+)、CD8^(+)细胞、PD-1水平与观察组患者临床病理特征的相关性。结果观察组的外周血CD4^(+)细胞低于对照组,CD8^(+)细胞、PD-1水平均明显高于对照组(P<0.05);不同肿瘤直径、TNM分期、分化程度、淋巴结转移患者外周血CD4^(+)、CD8^(+)细胞、PD-1水平比较,差异均有统计学意义(P<0.05);Pearson相关性分析显示,CD4^(+)细胞与肿瘤直径、TNM分期、分化程度、淋巴结转移均呈负相关,CD8^(+)细胞、PD-1与肿瘤直径、TNM分期、分化程度、淋巴结转移均呈正相关(P<0.05)。结论结直肠癌患者外周血CD4^(+)细胞降低,CD8^(+)细胞、PD-1水平升高,且与肿瘤直径、TNM分期、分化程度、淋巴结转移均具有相关性,应予以密切重视。
Objective To investigate the expression of peripheral blood CD4^(+)and CD8^(+)cells and programmed death factor-1(PD-1)in patients with colon cancer and its clinical significance.Methods 78 patients with colon cancer admitted to our hospital from August 2022 to August 2023 were selected as the observation group,and 70 healthy people who underwent physical examination in our hospital during the same period were selected as the control group.The peripheral blood CD4^(+),CD8^(+)cells and PD-1 levels in the two groups were compared,and peripheral blood CD4^(+),CD8^(+)cells and PD-1 in patients with different pathological characteristics of the observation group were compared,and the correlation between the peripheral blood CD4^(+),CD8^(+)cells and PD-1 levels and the clinicopathological characteristics of patients in the observation group was analyzed using Pearson correlation analysis method.Results The peripheral blood CD4^(+)cells in the observation group were lower than those in the control group,and CD8^(+)cells and PD-1 levels in the observation group were significantly higher than those in the control group(P<0.05).There were statistically significant differences in the peripheral blood CD4^(+),CD8^(+)cells and PD-1 in the patients with different tumor diameter,TNM stage,differentiation degree and lymph node metastasis(P<0.05).The Pearson correlation analysis showed that CD4^(+)cells was negatively correlated with tumor diameter,TNM stage,differentiation degree,and lymph node metastasis,while CD8^(+)cells and PD-1 were positively correlated with tumor diameter,TNM stage,differentiation degree,and lymph node metastasis(P<0.05).Conclusion The peripheral blood CD4^(+)cells in patients with colorectal cancer was decreased,and the CD8^(+)cells and PD-1 levels were increased,which were correlated with tumor diameter,TNM stage,differentiation degree,and lymph node metastasis.
作者
金晶
吴水莲
郭可俊
JIN Jing;WU Shuilian;GUO Kejun(Hangzhou Cancer Hospital,Zhejiang 310002,China)
出处
《浙江创伤外科》
2024年第1期7-9,13,共4页
Zhejiang Journal of Traumatic Surgery
