摘要
目的:调查江苏适碘地区农村老年人群甲状腺结节和甲状腺癌的患病率,并分析甲状腺结节患病的危险因素。方法:采用整群抽样的方法对江苏适碘地区进行横断面调查研究,选取2 590例60岁及以上的常驻居民进行体检与生化检查,采用甲状腺影像学报告及数据系统(Thyroid Imaging Reporting And Data System,TI-RADS)分类方法对甲状腺结节进行分类评估,并对部分甲状腺结节进行超声引导下活检病理检查,采用Logistic回归分析甲状腺结节的危险因素。结果:2 590例受者中共检出甲状腺结节883例,总体患病率为34.09%(883/2 590),女性患病率明显高于男性(χ^(2)=27.885,P=0.000),有甲状腺结节组和无甲状腺结节组相比,身高、体质指数、空腹血糖、糖化血红蛋白、空腹胰岛素、甘油三酯、25羟维生素D差异有统计学意义(分别为t=5.337、P=0.000,t=-5.160、P=0.000,t=-2.341、P=0.019,t=-4.993、P=0.000,t=-2.384、P=0.020,t=-2.940、P=0.003,t=6.432,P=0.000)。男性甲状腺结节的患病率随年龄的增加而增加。老年人甲状腺癌的总体检出率为0.34%。Logistic回归分析结果显示,体质指数和糖化血红蛋白是甲状腺结节患病的危险因素(OR=1.054,95%CI=1.028~1.081,P<0.01;OR=1.257,95%CI=1.117~1.414,P<0.01)。结论:甲状腺结节是老年人常见的甲状腺疾病,但甲状腺癌的患病率总体较低。糖脂代谢紊乱与甲状腺结节的患病密切相关。
Objective:To investigate the prevalence of thyroid nodules and thyroid cancer and the risk factors for thyroid nodules in a rural elderly population in iodine-sufficient areas of Jiangsu Province,China.Methods:A cross-sectional survey was performed in iodine-sufficient areas of Jiangsu Province,investigating a total of 2590 permanent residents aged≥60 years selected by cluster sam-pling.They underwent physical examination and biochemical tests.Thyroid nodules were classified using the Thyroid Imaging Report and Data System(TI-RADS),part of which were examined for pathological information through an ultrasound-guided biopsy.A logistic regression analysis was used to analyze the risk factors for thyroid nodules.Results:A total of 883 cases of thyroid nodules were detected in 2590 subjects.With an overall prevalence of 34.09%(883/2590).The prevalence of female subjects was signifi-cantly higher than that of male subjects(χ^(2)=27.885,P=0.000).There were significant differences in height(Ht),body mass index(BMI),fasting blood glucose(FBG),glycosylated hemoglobin(HbA1c),fasting insulin(FINS),triglyceride(TG),and 25-hydroxyvitamin D[25(OH)D]between the participants with and without thyroid nodules(t=5.337、P=0.000,t=-5.160、P=0.000,t=-2.341、P=0.019,t=-4.993、P=0.000,t=-2.384、P=0.020,t=-2.940、P=0.003,t=6.432、P=0.000,respectively).The prevalence of thyroid nodules in men increased with age.The overall detection rate of thyroid cancer in the elderly was 0.34%.The logistic regression analysis showed that the BMI and HbA1c hemoglobin were risk factors for thyroid nodules(OR=1.054,95%CI=1.028-1.081,P<0.01;OR=1.257,95%CI=1.117-1.414,P<0.01).Conclusion:Thyroid nodules are prevalent in the elderly in iodine-sufficient areas of Jiangsu Province,with a low prevalence of thyroid cancer.Glucose and lipid metabolism disorders are significantly related to the prevalence of thyroid nodules.
作者
张丽娜
倪文婧
张梦杰
密玮诺
孙宇
李兴佳
陈国芳
刘超
徐书杭
Zhang Lina;Ni Wenjing;Zhang Mengjie;Mi Weinuo;Sun Yu;Li Xingjia;Chen Guofang;Liu Chao;Xu Shuhang(Department of Endocrinology,Jiangsu Provincial Hospital of Integrated Traditional Chinese and Western Medicine/Affiliated Hospital of Integrated Traditional Chinese and Western Medicine,Nanjing University of Chinese Medicine;Department of Infectious Diseases,Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine;Department of Endocrinology,Suqian Hospital of Xuzhou Medical University)
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2024年第1期24-30,共7页
Journal of Chongqing Medical University
基金
2020年江苏省重点研发计划资助项目(编号:BE2020726)
2021年宿迁市重点研发计划项目(编号:S202110)
中华国际医学交流基金会甲状腺中青年医生研究资助项目(编号:BQE-JZX-202115)
江苏省卫生健康委,2020年度医学科研资助项目(面上项目)(编号:M2020102)。
