摘要
目的探究补中益气汤加味对胃癌手术后气虚血瘀证患者胃肠功能恢复及对免疫功能的影响。方法选取2019年3月至2021年3月于上饶东信第五医院行胃癌术后且表现为气虚血瘀的60例患者作为研究对象,随机分为观察组与对照组,每组30例。对照组行常规术后治疗,观察组在对照组治疗基础上联合补中益气汤加味治疗。比较两组术后7 d时中医证候积分及术后胃肠功能恢复情况(排便复常时间、排气复常时间、肠鸣音复常时间);比较术后1、3 d炎症细胞因子[肿瘤坏死因子-α(TNF)、白细胞介素-6(IL-6)、C反应蛋白(CRP)]水平、术后1、7 d免疫功能指标(IgA、IgG、IgM、CD4^(+)/CD8^(+));比较术后1 d、1个月胃肠激素[血清胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、促胃液素(GS)]水平。结果观察组倦怠乏力、食少纳呆、食后腹胀、大便稀溏评分及总分均低于对照组,差异有统计学意义(P<0.05)。观察组术后排便复常时间、排气复常时间、肠鸣音复常时间均短于对照组,差异有统计学意义(P<0.05)。术后1 d,两组IL-6、CRP、TNF-α水平比较差异无统计学意义;术后3 d,两组IL-6、CRP、TNF-α水平均明显高于术后1 d,但观察组低于对照组,差异有统计学意义(P<0.05)。术后1 d,两组IgA、IgG、IgM水平及CD4^(+)/CD8^(+)比较差异无统计学意义;术后7 d,两组IgA、IgG、IgM水平及CD4^(+)/CD8^(+)均明显高于术后1 d,且观察组IgA、IgG、IgM水平均高于对照组,但CD4^(+)/CD8^(+)低于对照组,差异有统计学意义(P<0.05)。术后1 d,两组PGⅠⅠ、PGⅡ、GS水平比较差异无统计学意义;术后1个月,两组PGⅠ、PGⅡ水平均高于术后1 d,GS水平均低于术后1 d,且观察组PGⅠ、PGⅡ水平高于对照组,GS水平低于对照组,差异有统计学意义(P<0.05)。结论补中益气汤加味能促进胃癌术后气虚血瘀证的患者胃肠道功能恢复,缓解术后不适症状,有效提升患者自身免疫功能,值�
Objective To explore the effect of modified Buzhong Yiqi decoction on gastrointestinal function recovery and immune function in patients with qi deficiency and blood stasis syndrome after gastric cancer surgery.Methods 60 patients with qi deficiency and blood stasis after gastric cancer surgery in Shangrao Dongxin Fifth Hospital from March 2019 to March 2021 were selected as the study subjects,and they were randomly divided into the observation group and the control group,with 30 cases in each group.The control group received routine postoperative treatment,and the observation group was given modified Buzhong Yiqi decoction on the basis of the control group.The Traditional Chinese Medicine syndromes scores at 7 d after surgery and postoperative gastrointestinal function recovery(defecation recovery time,exhaust recovery time,bowel sound recovery time),levels of inflammatory cytokines(tumor necrosis factor-α[TNF],interleukin-6[IL-6],C-reactive protein[CRP])at 1,3 d after surgery,immune function indicators(IgA,IgG,IgM,CD4+/CD8^(+))at 1 and 7 d after surgery and levels of gastrointestinal hormones(serum pepsinogenⅠ[PGⅠ],pepsinogenⅡ[PGⅡ,gastrin[GS])at 1 d and 1 month after surgery were compared between the two groups.Results The scores of fatigue,poor appetite,abdominal distension after meal and thin sloppy stool and total score in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The postoperative defecation recovery time,exhaust recovery time and bowel sound recovery time in the observation group were shorter than those in the control group,the differences were statistically significant(P<0.05).At 1 d after surgery,there were no statistically significant differences in IL-6,CRP and TNF-αlevels between the two groups;at 3 d after surgery,the levels of IL-6,CRP and TNF-αof the two groups were significantly higher than those at 1 d after surgery,but the observation group were lower than the control group,the differences were statistic
作者
柯维芳
骆启春
邱模军
周璐
KE Weifang;LUO Qichun;QIU MuJun;ZHOU Lu(Shangrao Dongxin Fifth Hospital,Shangrao Fifth People's Hospital,Shangrao,Jiangxi,334000,China)
出处
《当代医学》
2023年第33期58-61,共4页
Contemporary Medicine
关键词
补中益气汤
胃癌
气虚血瘀
胃肠道功能
免疫系统
Buzhong Yiqi decoction
Gastric cancer
Qi deficiency and blood stasis
Gastrointestinal function
Immune system
