摘要
目的:观察加味柴胡汤联合帕罗西汀对抑郁症患者贝克抑郁量表(beck depression inventory,BDI)评分、血清神经元特异性烯醇化酶(neuronspecific enolase,NSE)水平、汉密尔顿抑郁量表(Hamilton depression scale,HAMD)评分及自杀意念自评量表(self-rating idea of suicide scale,SIOSS)评分的影响。方法:将108例抑郁症患者按照随机数字表法分为对照组和研究组各54例。对照组口服帕罗西汀,研究组在对照组基础上给予加味柴胡汤,治疗8周后比较两组疗效,并比较治疗前及治疗4、8周后BDI评分、血清NSE水平、HAMD评分、SIOSS评分及两组不良反应发生率。结果:研究组患者总有效率为92.59%(50/54),高于对照组的75.93%(41/54)(P<0.05)。治疗4、8周后两组患者HAMD、BDI、SIOSS评分及血清NSE水平较治疗前降低(P<0.05),研究组低于对照组(P<0.05)。两组患者不良反应发生率比较差异无统计学意义(P>0.05)。结论:加味柴胡汤联合帕罗西汀能有效缓解抑郁症患者抑郁状况,降低血清NSE水平,效果优于单用帕罗西汀。
Objective:To explore the influence of modified Chaihu Tang and paroxetine on BDI scores,the levels of NSE and SIOSS in patients with depression.Methods:All 108 patients were allocated to the control group and the study group with 54 cases in each group using random number table method.The control group was given paroxetine orally,and the study group took modified Chaihu Tang based on Western medicine,to compare clinical effects after eight weeks of treatment,HAMD scores before the treatment,after four and eight weeks of the treatment,BDI scores,the levels of serum NSE,SIOSS scores,and compare the incidence of adverse reaction between both groups.Results:Total effective rate of the study group was 92.59%(50/54),higher than 75.93%(41/54)of the control group(P<0.05).After four and eight weeks of the treatment,HAMD,BDI,SIOSS scores and the levels of serum NSE of both groups were lower than these before the treatment(P<0.05),the study group was lower than the control group(P<0.05).The difference had no statistical meaning in the incidences of adverse reaction between both groups(P>0.05).Conclusion:Modified Chaihu Tang and paroxetine could effectively relieve the patients'depression,reduce the levels of serum NSE and suicide attempts,and its effects superior to these of paroxetine.
作者
李静
LI Jing(Department of Psychiatry,Guanggu Branch,Hubei Provincial Hospital of TCM,Wuhan 430061,China)
出处
《西部中医药》
2024年第1期132-135,共4页
Western Journal of Traditional Chinese Medicine
