摘要
目的 探讨针刺华佗夹脊穴联合雷火灸治疗中风后偏瘫的疗效及对血清神经元特异性烯醇化酶(NSE)和S100β蛋白水平的影响。方法 选取2021年1月至2022年1月于武汉市中医医院就诊的中风后偏瘫病人92例,按照随机数字表法分为对照组和观察组(n=46),两组病人均接受常规营养神经、活血化瘀等药物治疗,对照组病人除基础治疗外加用雷火灸,观察组病人在对照组的基础上给予针刺华佗夹脊穴治疗,治疗周期4周。观察两组肢体肿胀程度、功能独立性量表(FIM)评分、Berg平衡功能量表(BBS)评分、疗效、血清NSE和S100β蛋白水平及不良反应发生率。结果 治疗2周、4周后,两组肢体肿胀积分[(1.43±0.59)分比(1.67±0.41)分、(0.16±0.32)分比(0.31±0.29)分]及血清NSE[(0.31±0.08)μg/L比(0.39±0.10)μg/L、(0.18±0.05)μg/L比(0.25±0.07)μg/L]、S100β蛋白[(21.99±5.67)μg/L比(25.08±6.41)μg/L、(14.34±3.65)μg/L比(18.26±4.70)μg/L]水平均显著降低,且观察组低于对照组(P<0.05);治疗2周、4周后,两组FIM评分[(68.54±10.22)分比(62.39±8.49)分、(83.54±15.61)分比(73.37±11.24)分]、BBS评分[(28.54±6.39)分比(25.21±4.70)分、(37.82±8.64)分比(32.87±7.21)分]均显著升高,且观察组高于对照组(P<0.05);观察组整体疗效优于对照组(P<0.05);观察组不良反应发生率(4.35%)与对照组(2.17%)比较差异无统计学意义(P>0.05)。结论 针刺华佗夹脊穴联合雷火灸对中风后偏瘫病人疗效显著,可有效提高FIM评分及降低血清NSE、S100β蛋白水平,改善病人平衡能力及肢体肿胀症状,且安全性较高。
Objective To explore the therapeutic effect of acupuncture at Huatuo Jiaji point combined with thunder-fire moxibustion on post-stroke hemiplegia and its influence on serum neuron-specific enolase(NSE)and S100βprotein levels.Methods Ninety-two patients with post-stroke hemiplegia,who visited Wuhan Hospital of Traditional Chinese Medicine from January 2021 to January 2022,were included in this study.They were randomly grouped into control group(n=46)and observation group(n=46)according to the ran⁃dom number table.Both groups received conventional drug therapy such as nourishing nerves,promoting blood circulation and remov⁃ing blood stasis,etc,and meanwhile,the control group received thunder-fire moxibustion in addition to the basic treatment,the observa⁃tion group acupuncture at Huatuo Jiaji point additionally,and the treatment cycle was 4 weeks.Observation was made of the degree of limb swelling,functional independence measure(FIM)scores,Berg Balance Scale(BBS)scores,curative effect,serum NSE and S100βprotein levels,and incidence of adverse reactions in the two groups.Results After 2 weeks and 4 weeks of treatment,the limb swelling scores[(1.43±0.59)vs.(1.67±0.41),(0.16±0.32)vs.(0.31±0.29)]and serum NSE[(0.31±0.08)μg/L vs.(0.39±0.10)μg/L,(0.18±0.05)μg/L vs.(0.25±0.07)μg/L]and S100βprotein levels[(21.99±5.67)μg/L vs.(25.08±6.41)μg/L,(14.34±3.65)μg/L vs.(18.26±4.70)μg/L]were significantly decreased in both groups,and the observation group was lower than the control group(P<0.05).After 2 weeks and 4 weeks of treatment,the FIM scores[(68.54±10.22)vs.(62.39±8.49),(83.54±15.61)vs.(73.37±11.24)]and BBS scores[(28.54±6.39)vs.(25.21±4.70),(37.82±8.64)vs.(32.87±7.21)]of the two groups were obviously increased,and the observation group was higher than the control group(P<0.05).The overall effecacy in the observation group was better than that in the control group(P<0.05).The observa⁃tion group(4.35%)and the control group(2.17%)were not obviously different in the incidence of adverse re
作者
金玉
王非
张京兰
金海涛
杨晶
姜磊
JIN Yu;WANG Fei;ZHANG Jinglan;JIN Haitao;YANG Jing;JIANG Lei(Department of Encephalopathy,Wuhan Hospital of Traditional Chinese Medicine,Wuhan,Hubei 430000,China)
出处
《安徽医药》
CAS
2024年第2期309-313,共5页
Anhui Medical and Pharmaceutical Journal
基金
武汉市医学科研项目(WZ20C41)。
