摘要
目的对比分析早期肺鳞状细胞癌(lung squamous cell carcinoma,LUSC)和肺腺癌(lung adenocarcinoma,LUAD)患者立体定向放射治疗(stereotactic body radiation therapy,SBRT)后的预后。方法应用回顾性研究方法。通过收集早期非小细胞肺癌(non small cell lung cancer,NSCLC)患者病历资料对其进行调查。根据患者的组织学类型将其分为LUSC和LUAD两组患者,对比分析两组患者的一般资料和预后状况。结果(1)较之于LUAD组,LUSC组的5年生存率(OS和PFS)均明显偏低,LR(局部复发)率明显偏高,P<0.05。两组的DM(远处转移)率相近,P>0.05。(2)年龄大、男性、肿瘤直径大、组织学类型为LUSC是早期NSCLC患者5年OS的危险因素(P<0.05),HR分别为1.201、2.245、1.378、1.804。HR的95%CI值分别为:1.041~1.386、1.535~3.285、1.090~1.744、1.207~2.696。(3)PS评分高、肿瘤直径大、组织学类型为LUSC是早期NSCLC患者5年PFS的危险因素(P<0.05),HR分别为:1.876、1.205、1.973。HR的95%CI值分别为:1.352~2.602、1.038~1.398、1.258~3.098。(4)肿瘤直径大、组织学类型为LUSC是早期NSCLC患者5年局部复发的危险因素(P<0.05),HR分别为1.273、2.249。HR的95%CI值分别为:1.075~1.506、1.364~3.705。结论SBRT后LUSC患者的OS率和PFS率均低于LUAD患者;LUSC患者的LR风险高于LUAD患者。
Objective To compare and analyze the prognosis of early stage lung squamous cell carcinoma(LUSC)and lung adenocarcinoma(LUSC)after stereotactic body radiation therapy(SBRT).Methods Retrospective study was used.Patients with early NSCLC were investigated by collecting their medical records.The patients were divided into the LUSC group and the LUAD group according to their histological types,and their general data and prognosis of the two groups were compared and analyzed.Results(1)Compared with the LUAD group,the 5-year survival rate(OS and PFS)of the LUSC group was significantly lower,while the LR(local recurrence)rate was significantly higher(P<0.05).The DM(distant metastasis)rates of the two groups were similar(P>0.05).(2)Age,male gender,large tumor diameter and histological type of LUSC were risk factors for 5-year OS in early NSCLC patients(P<0.05),with HR of 1.201,2.245,1.378,and 1.804,respectively.The 95%CI values of HR were 1.041~1.386,1.535~3.285,1.090~1.744,and 1.207~2.696,respectively.(3)High PS score,large tumor diameter and histological type of LUSC were risk factors for 5-year PFS in early NSCLC patients(P<0.05),with HR of 1.876,1.205 and 1.973,respectively.The 95%CI values of HR were1.352~2.602,1.038~1.398 and 1.258~3.098,respectively.⑷Large tumor diameter and histological type of LUSC were risk factors for 5-year local recurrence in early NSCLC patients(P<0.05),with HR of 1.273 and 2.249,respectively.The 95%CI values of HR were 1.075~1.506 and 1.364~3.705,respectively.Conclusion The OS and PFS rates of LUSC patients after SBRT are lower than those of LUAD patients.The LR risk of LUSC patients is higher than that of LUAD patients.
作者
何志杰
HE Zhijie(Department of Radiotherapy,Anyang Cancer Hospital,Anyang,Henan 455000,China)
出处
《临床肺科杂志》
2024年第2期242-248,共7页
Journal of Clinical Pulmonary Medicine
关键词
肺癌
放疗
复发
lung cancer
radiotherapy
recrudescence
