摘要
目的通过定量检测冠心病(CHD)患者的血清淀粉样蛋白A(SAA)和C反应蛋白(CRP)水平,分析血清SAA、CRP联合检测对冠心病的诊断、评估价值。方法选择180例冠心病患者为试验组、120例健康体检者为对照组。检测两组血清SAA、CRP水平。对比两组血清SAA、CRP水平,试验组不同临床表型[急性心肌梗死(AMI)、不稳定型心绞痛(UAP)、稳定型心绞痛(SAP)]的血清SAA、CRP水平。结果试验组的SAA和CRP分别为(22.651±12.330)mg/L和(19.504±12.040)mg/L,对照组的SAA和CRP分别为(2.696±0.930)mg/L和(2.410±1.100)mg/L,试验组患者血清SAA、CRP显著高于对照组(P<0.05);试验组不同临床表型患者中,AMI的SAA和CRP分别为(40.379±5.439)mg/L和(35.699±5.065)mg/L,UAP的SAA和CRP分别为(15.828±1.933)mg/L和(13.094±1.764)mg/L,SAP的SAA和CRP分别为(11.746±1.931)mg/L和(9.718±1.224)mg/L,试验组不同临床表型患者血清SAA和CRP水平比较,AMI>UAP>SAP(P<0.05)。结论冠心病与健康人群的血清SAA、CRP水平有明显差异,且不同临床表型的冠心病患者血清SAA、CRP水平不同,检测血清SAA、CRP水平可提高冠心病的诊断准确性,同时能够反映冠心病的严重程度,从而指导临床医生的治疗。
Objective To analyze the diagnostic and evaluation value of serum amyloid A(SAA)and C-reactive protein(CRP)in coronary heart disease(CHD)by quantitatively detecting the levels of SAA and CRP.Methods 180 patients with coronary heart disease were selected as an experimental group and 120 healthy subjects were selected as a control group.SAA and CRP levels of the two groups were detected respectively.The levels of SAA and CRP were compared between the two groups,as well as the levels of SAA and CRP in patients with different clinical phenotypes of coronary heart disease[acute myocardial infarction(AMI),unstable angina pectoris(UAP),stable angina pectoris(SAP)].Results SAA and CRP in the experimental groups were(22.651±12.330)mg/L and(19.504±12.040)mg/L,respectively;SAA and CRP in the control group were(2.696±0.930)mg/L and(2.410±1.100)mg/L,respectively.SAA and CRP in the experimental group were significantly higher than those in the control group(P<0.05).Among patients with different clinical phenotypes,SAA and CRP in AMI patients were(40.379±5.439)and(35.699±5.065)mg/L,respectively;SAA and CRP were(15.828±1.933)and(13.094±1.764)mg/L in UAP patients,respectively;SAA and CRP were(11.746±1.931)and(9.718±1.224)mg/L in SAP patients,respectively.The levels of SAA and CRP in patients with different clinical phenotypes of the experimental group were compared,AMI>UAP>SAP(P<0.05).Conclusion There are significant differences in the levels of SAA and CRP between coronary heart disease and healthy people,and the serum levels of SAA and CRP are different in coronary heart disease patients with different clinical phenotypes.Detection of SAA and CRP levels can improve the diagnostic accuracy of coronary heart disease,and reflect the severity of coronary heart disease,so as to guide the treatment of clinicians.
作者
梁知锐
余飞燕
曾庆栈
徐耀祥
赖苑双
LIANG Zhi-rui;YU Fei-yan;ZENG Qing-zhan(Department of Laboratory,Yangjiang Hospital of Traditional Chinese Medicine,Yangjiang 529500,China)
出处
《中国实用医药》
2024年第1期82-85,共4页
China Practical Medicine
关键词
冠心病
血清淀粉样蛋白A
C反应蛋白
诊断
Coronary heart disease
Serum amyloid protein A
C-reactive protein
Diagnosis
