摘要
目的观察沙参麦门冬汤加减辅治慢性支气管炎的效果及对炎性因子的影响。方法选取2019年9月—2021年9月湛江市第一中医医院收治的慢性支气管炎患者60例,根据随机抽签法分为观察组和对照组,每组30例。对照组采取常规治疗,观察组在对照组基础上给予沙参麦门冬汤加减辅助治疗,2组均以治疗7 d作为1个疗程,共治疗3个疗程。比较2组患者治疗效果,治疗前后血清炎性因子[肿瘤坏死因子-α(TNF-α)、白介素-8(IL-8)和白介素-10(IL-10)]、临床症状积分,症状改善时间、住院时间及不良反应。结果观察组患者治疗总有效率为93.33%,高于对照组的63.33%(χ^(2)=7.954,P=0.005)。治疗3个疗程后,2组患者血清TNF-α、IL-8水平较治疗前降低,IL-10水平较治疗前升高,且观察组降低/升高幅度大于对照组(P<0.05或P<0.01);对照组患者治疗前后临床症状积分比较差异无统计学意义(P>0.05),观察组患者治疗3个疗程后临床症状积分低于治疗前与对照组(P均<0.01)。观察组患者症状改善时间和住院时间均短于对照组(P<0.01);观察组不良反应总发生率为10.00%,低于对照组的33.33%(χ^(2)=4.812,P=0.028)。结论沙参麦门冬汤加减辅助治疗慢性支气管炎的效果显著,同时可减轻机体炎性反应,缩短症状改善时间和住院时间,且不良反应发生率低。
Objective To observe the effect of modified Shashen Maimendong decoction on chronic bronchitis and its effect on inflammatory factors.Methods A total of 60 patients with chronic bronchitis admitted to the Zhanjiang First Hospital of Traditional Chinese Medicine from September 2019 to September 2021 were selected and randomly divided into observation group and control group,with 30 cases in each group.The control group was treated with conventional treatment,while the observation group was treated with modified Shashen Maimendong decoction on the basis of the control group.Two groups were treated for 7 days as a course of treatment,a total of 3 courses of treatment.The treatment effect,and the serum inflammatory factors(TNF-α,IL-8,IL-10),clinical symptom score,symptom improvement time,hospital stay,and adverse reactions of the two groups were compared.Results The total effective rate of the observation group was 93.33%,higher than 63.33%of the control group(χ^(2)=7.954,P=0.005).After 3 courses of treatment,the levels of the serum TNF-α,IL-8 of patients in two groups were lower than those before treatment,and the levels of IL-10 were higher than those before treatment,and the decrease/increase amplitude of the observation group was greater than that of the control group(P<0.05 or P<0.01);There was no significant difference in the clinical symptom score between the control group before and after treatment(P>0.05),and the clinical symptom scores of the observation group after 3 courses of treatment were lower than those of the control group before treatment(P<0.01).The symptom improvement time and hospitalization time of the observation group were shorter than those of the control group(P<0.01);The total incidence of adverse reactions in the observation group was 10.00%,which was lower than 33.33%in the control group(χ^(2)=4.812,P=0.028).Conclusion The effect of modified Shashen Maimendong decoction in the adjuvant treatment of chronic bronchitis is significant,while it can reduce the body inflammatory reaction,s
作者
李欣
LI Xin(Intensive Care Unit,Zhanjiang First Hospital of Traditional Chinese Medicine,Guangdong Province,Zhanjiang 524043,China)
出处
《临床合理用药杂志》
2024年第2期8-10,14,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
慢性支气管炎
沙参麦门冬汤
炎性因子
症状积分
Chronic bronchitis
Shashen Maimendong decoction
Inflammatory factors
Clinical symptom score
