摘要
目的比较水刀磨削或电动磨削联合负压吸疱自体表皮移植术治疗白癜风的临床疗效和安全性。方法前瞻性纳入2020年3月至2022年3月西京皮肤医院门诊60例白癜风患者,其中30例采用水刀磨削法,30例采用电动磨削法,然后均联合负压吸疱自体表皮移植术。术后每月复诊1次,6个月后评估组间色素恢复情况和疗效差异。结果水刀磨削组30例(312片皮损),男13例,女17例,年龄(24.41±3.12)岁,病程(5.13±2.34)年;电动磨削组30例(301片皮损),男11例,女19例,年龄(22.73±5.11)岁,病程(4.88±2.21)年。两组年龄、性别、病程及磨削部位分布差异无统计学意义(均P>0.05)。水刀磨削组皮损痊愈187处(59.94%)、显效103处(33.01%)、有效22处(7.05%);电动磨削组痊愈166处(55.15%)、显效108处(35.88%)、有效27处(8.97%);两组总有效率(92.95%比91.03%)差异无统计学意义(χ^(2)=0.27,P=0.602)。水刀磨削组色素恢复程度(90.47%±2.53%)、色素匹配度[(3.53±0.21)分]、患者满意度[(3.32±0.27)分]均高于电动磨削组[82.40%±5.33%、(2.71±0.32)分、(2.68±0.41)分,t=5.30、8.28、5.09,均P<0.05]。两组均未见不良反应/事件。结论水刀磨削与电动磨削联合负压吸疱自体表皮移植术治疗白癜风的疗效相似,安全性好,但采用水刀磨削的患者色素恢复程度、色素匹配度、患者满意度优于电动磨削。
Objective To compare the clinical efficacy and safety of water jet-assisted dermabrasion versus electric dermabrasion in combination with suction blister epidermal grafting in the treatment of vitiligo.Methods A total of 60 vitiligo patients were enrolled from the Department of Dermatology,Xijing Hospital from March 2020 to March 2022.Thirty patients firstly received water jet-assisted dermabrasion,30 firstly received electric dermabrasion,and then all were treated with suction blister epidermal grafting.Follow-up visits were conducted once a month,and the repigmentation of skin lesions and efficacy were evaluated and compared between the two groups 6 months after surgery.Results There were 30 patients with 312 skin lesions in the water jet-assisted dermabrasion group,including 13 males and 17 females,with the ages and disease duration being 24.41±3.12 years and 5.13±2.34 years respectively;there were 30 patients with 301 skin lesions in the electric dermabrasion group,including 11 males and 19 females,with the ages and disease duration being 22.73±5.11 years and 4.88±2.21 years respectively.No significant differences were observed in the age,gender,disease duration,and dermabrasion sites between the two groups(all P>0.05).Six months after the operation,187(59.94%)skin lesions were healed,103(33.01%)were markedly improved,and 22(7.05%)were improved in the water jet-assisted dermabrasion group;in the electric dermabrasion group,166(55.15%)lesions were healed,108(35.88%)were markedly improved,and 27(8.97%)were improved;there was no significant difference in the total response rate between the water jet-assisted dermabrasion group(92.95%)and the electric dermabrasion group(91.03%;χ^(2)=0.27,P=0.602).The water jet-assisted dermabrasion group showed significantly higher degree of repigmentation(90.47%±2.53%),matching degree of skin color(3.53±0.21 points),and patient satisfaction scores(3.32±0.27 points)compared with the electric dermabrasion group(82.40%±5.33%,2.71±0.32 points,2.68±0.41 points,t=5.30,8.28,
作者
陈慧
李冰
李春英
郭伟楠
Chen Hui;Li Bing;Li Chunying;Guo Weinan(Department of Dermatology,Xijing Hospital,Air Force Medical University,Xi′an 710032,China)
出处
《中华皮肤科杂志》
CSCD
北大核心
2024年第1期43-45,共3页
Chinese Journal of Dermatology
关键词
白癜风
移植
自体
皮肤移植
水刀磨削
电动磨削
负压吸疱
疗效比较
Vitiligo
Transplantation,autologous
Skin transplantation
Water jet-assisted dermabrasion
Electric dermabrasion
Suction blister
Efficacy comparison
