摘要
鼻咽癌是临床上常见的恶性肿瘤之一。以顺铂为代表药物的化学药物治疗和放射治疗是目前治疗鼻咽癌的主要手段。多发的肿瘤化疗药物耐药现象为鼻咽癌的治疗带来极大困扰。鼻咽癌顺铂耐药机制可以概括为6个方向:增加细胞内药物浓度、减少顺铂的失活物质、增加DNA损伤和抑制损伤修复、促进细胞凋亡、调节肿瘤微环境、抑制胞内自噬。对鼻咽癌细胞在顺铂的耐药性中的研究进展作简要综述,为逆转鼻咽癌顺铂耐药以及寻找天然、安全、有效的化学药物治疗增敏剂的研究提供方向。
Nasopharyngeal carcinoma(NPC)is one of the common malignant tumors in clinic.Currently,chemotherapy with cisplatin as the representative drug and radiotherapy are the main treatment options for NPC,but the high chemoresistance could pose significant challenges.The mechanisms of cisplatin resistance in NPC can be summarized into six aspects,namely increasing intracellular drug concentration,reducing cisplatin inactivation,enhancing DNA damage and inhibiting damage repair,promoting apoptosis,regulating tumor microenvironment,and inhibiting intracellular autophagy.Hence,this paper briefly reviews the research progress on cisplatin resistance in NPC cells,aiming to offer research directions for reversing cisplatin resistance in NPC and finding natural,safe,and effective chemotherapeutic sensitizers.
作者
黄钧伟
邓晗薇
杨美丽
宾骥
朱镇华
HUANG Junwei;DENG Hanwei;YANG Meili;BIN Ji;ZHU Zhenhua(The First Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410007,China)
出处
《湖南中医药大学学报》
CAS
2024年第1期163-168,共6页
Journal of Hunan University of Chinese Medicine
基金
湖南省中医耳鼻喉临床医学研究中心(2020SK4024)
2023年湖南省研究生科研创新项目(CX20230798)。
关键词
鼻咽癌
顺铂
耐药机制
凋亡
逆转耐药
抗氧化应激
研究进展
nasopharyngeal carcinoma
cisplatin
resistance mechanism
apoptosis
reversing drug resistance
anti-oxidative stress
research progress
