摘要
目的探究基质金属蛋白酶组织抑制剂(TIMP)-1、正五聚素蛋白(PTX3)在阻塞性睡眠呼吸暂停低通气综合征(OSAHS)患者血清中的表达情况及其临床意义。方法选取该院2021-2022年收治的120例OSAHS患者为研究组,另外选取同期该院的体检健康者114例为对照组。根据呼吸紊乱指数(AHI)及最低血氧饱和度(LSpO 2)判断OSAHS的严重程度,将患者分为轻度组(66例)和中重度组(54例),采用酶联免疫吸附试验检测血清TIMP-1、PTX3水平,Pearson法分析研究组血清TIMP-1、PTX3水平与AHI、LSpO 2的相关性。受试者工作特征(ROC)曲线分析血清TIMP-1、PTX3对OSAHS患者病情严重程度的预测价值。Logistic回归分析OSAHS患者病情严重程度的影响因素。结果研究组血清TIMP-1、PTX3、AHI水平均高于对照组,LSpO 2水平低于对照组(P<0.05);中重度组体质量指数(BMI)、高血压史比例、冠心病史比例、总胆固醇、三酰甘油、低密度脂蛋白胆固醇、TIMP-1、PTX3、AHI水平高于轻度组,高密度脂蛋白胆固醇、LSpO 2水平低于轻度组(P<0.05);经Pearson法分析,血清TIMP-1、PTX3水平与AHI呈正相关(r=0.428、0.392,P<0.05),血清TIMP-1、PTX3水平与LSpO 2呈负相关(r=-0.645、-5.836,P<0.05);ROC曲线结果显示,血清TIMP-1和PTX3单独预测患者病情严重程度的曲线下面积(AUC)分别为0.813和0.777,最佳截断值分别为2.47μg/L和7.23 ng/L,灵敏度分别为70.37%和77.78%,特异度分别为77.27%和72.23%,二者联合预测患者病情严重程度的AUC为0.866,明显高于血清TIMP-1(Z=2.067,P=0.039)和PTX3单独预测(Z=2.331,P=0.020)。Logistic回归分析显示,TIMP-1、PTX3、高血压史、冠心病史、AHI、LSpO 2是OSAHS患者病情严重程度的影响因素(P<0.05)。结论TIMP-1、PTX3在OSAHS患者血清中均表达上调,与疾病的严重程度密切相关,且是OSAHS患者病情严重程度的影响因素。
Objective To explore the expression and clinical significance of tissue inhibitor of matrix metalloproteinases(TIMP)-1 and pentraxin-3(PTX3)in the serum of patients with obstructive sleep apnea-hypopnea syndrome(OSAHS).Methods A total of 120 patients with OSAHS admitted to the hospital from 2021 to 2022 were selected as the study group,and another 114 healthy people who underwent the physical examination in the same period were selected as the control group.The severity of OSAHS was determined according to the apnea-hypopnea index(AHI)and the minimum oxygen saturation(LSpO_(2)),and the patients were divided into mild group(66 cases)and the moderate-severe group(54 cases).Serum TIMP-1 and PTX3 levels were measured by enzyme-linked immunosorbent assay.Pearson method was used to analyze the correlation between serum TIMP-1,PTX3 and AHI,LSpO 2.Receiver operating characteristic(ROC)curve was used to analyze the predictive value of serum TIMP-1 and PTX3 on the severity of disease in patients with OSAHS.Logistic regression was used to analyze the factors influencing the severity of the disease in OSAHS patients.Results Serum TIMP-1,PTX3 and AHI levels in the study group were higher than those in the control group,and LSpO 2 level was lower than that in the control group(P<0.05).The body mass index(BMI),the proportion of hypertension history,the proportion of coronary heart disease history,the levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol,TIMP-1,PTX3 and AHI in the moderate-severe group were significantly higher than those in the mild group,and the high density lipoprotein cholesterol,LSpO 2 level was significantly lower than that in the mild group(P<0.05).Pearson method results showed that serum TIMP-1,PTX3 levels were positively correlated with AHI(r=0.428,0.392,P<0.05),and serum TIMP-1,PTX3 levels were negatively correlated with LSpO 2(r=-0.645,-5.836,P<0.05).The results of the ROC curve showed that the area under the curve(AUC)of serum TIMP-1 and PTX3 alone predicted the severity of th
作者
王晖
张金洪
王红
孙美玉
赵文义
曹娟
张珍珍
孙广洁
WANG Hui;ZHANG Jinhong;WANG Hong;SUN Meiyu;ZHAO Wenyi;CAO Juan;ZHANG Zhenzhen;SUN Guangjie(Department of Respiratory and Critical Care Medicine,Cangzhou People′s Hospital,Cangzhou,Hebei 061000,China;Second Department of Psychiatry,Cangzhou People′s Hospital,Cangzhou,Hebei 061000,China)
出处
《国际检验医学杂志》
CAS
2024年第2期141-145,共5页
International Journal of Laboratory Medicine
基金
河北省医学科学研究课题计划(20220311)。
