摘要
目的:观察清热化痰活血方联合阿奇霉素治疗小儿支原体肺炎(MPP)痰热闭肺证的临床疗效及对炎症因子的影响。方法:按随机数字表法将110例MPP痰热闭肺证患儿分为对照组、治疗组各55例。对照组给予阿奇霉素治疗,治疗组在对照组基础上加用清热化痰活血方治疗,2组连续治疗16 d。比较2组治疗前后中医证候积分、血气分析指标及血清炎症因子水平,评估2组临床疗效与不良反应发生情况。结果:治疗后,对照组总有效率85.45%,低于治疗组98.18%(P<0.05)。治疗后,2组中医证候积分(发热、咳嗽、咳痰)及血清肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、C-反应蛋白(CRP)水平均较治疗前降低(P<0.05),血氧分压(PO_(2))、二氧化碳分压(PCO_(2))、血红蛋白(Hb)、血氧饱和度(SaO_(2))水平均升高(P<0.05);治疗组治疗后中医证候积分、血清炎症因子水平均低于对照组(P<0.05),血气分析指标高于对照组(P<0.05)。治疗组不良反应发生率3.64%,低于对照组18.18%(P<0.05)。结论:清热化痰活血方联合阿奇霉素治疗小儿MPP痰热闭肺证疗效显著,能改善患儿临床症状和血气指标,降低机体炎性反应,安全性较高。
Objective:To observe the clinical effect of Qingre Huatan Huoxue Prescription combined with Azithromycin on mycoplasma pneumoniae pneumonia(MPP)in children with the syndrome of phlegmheat obstructing the lung and its effects on inflammatory factors.Methods:A total of 110 cases of MMP children with the syndrome of phlegm-heat obstructing the lung were divided into the control group and the treatment group according to the random number table method,with 55 cases in each group.The control group was treated with Azithromycin,and the treatment group was additionally treated with Qingre Huatan Huoxue Prescription based on the treatment of the control group.Both groups were continuously treated for 16 days.Traditional Chinese medicine(TCM)syndrome scores,blood gas analysis indicators,and the levels of serum inflammatory factors were compared between the two groups before and after treatment.Clinical effects and the incidence of adverse reactions were evaluated in the two groups.Results:After treatment,the total effective rate was 85.45%in the control group,lower than that of 98.18%in the treatment group(P<0.05).After treatment,TCM syndrome scores(fever,cough,expectoration)and the levels of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),and C-reactive protein(CRP)in serum in the two groups were decreased when compared with those before treatment(P<0.05),and the levels of partial pressure of oxygen in blood(PO_(2)),partial pressure of carbon dioxide(PCO_(2)),hemoglobin(Hb),and blood oxygen saturation(SaO_(2))were increased(P<0.05);TCM syndrome scores and the levels of serum inflammatory factors in the treatment group were lower than those in the control group(P<0.05),and blood gas analysis indicators in the treatment group were higher than those in the control group(P<0.05).The incidence of adverse reactions was 3.64%in the treatment group,lower than that of 18.18%in the control group(P<0.05).Conclusion:Qingre Huatan Huoxue Prescription combined with Azithromycin has a significant curative effect in the treatment o
作者
苏洁
吴婷
况琦
SU Jie;WU Ting;KUANG Qi(Department of Pharmacy,Lishui Hospital of Traditional Chinese Medicine,Lishui Zhejiang 323000,China;Department of Pediatrics,Lishui Hospital of Traditional Chinese Medicine,Lishui Zhejiang 323000,China)
出处
《新中医》
CAS
2023年第23期158-162,共5页
New Chinese Medicine
关键词
小儿支原体肺炎
痰热闭肺证
清热化痰活血方
阿奇霉素
炎症因子
Mycoplasma pneumoniae pneumonia in children
Syndrome of phlegm-heat obstructing the lung
Qingre Huatan Huoxue Prescription
Azithromycin
Inflammatory factors
