摘要
肺炎支原体肺炎(Mycoplasma pneumoniae pneumonia,MPP)是由肺炎支原体(Mycoplasma pneumoniae,MP)引起的儿童下呼吸道感染,也是儿科最常见的非典型肺炎之一。近年来MPP发病率居高不下,且重症病例,如重症MPP及难治性MPP日趋增多,故早期诊断、识别重症病例对临床治疗显得尤为重要。白细胞介素-6(interleukin-6,IL-6)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)为炎性细胞因子,D-Dimer为纤维蛋白降解产物,研究表明MPP患儿血清IL-6、TNF-α、D-Dimer升高,且重症高于轻症,提示以上指标对MPP严重程度有提示作用,可作为早期识别重症病例及判断预后的参考指标。作者对近年来IL-6、TNF-α、DDimer对MPP患儿的价值及意义的研究进展进行综述。
Mycoplasma pneumoniae pneumonia (MPP) is a childhood lower respiratory tract infection caused by Mycoplasma pneumoniae (MP) and is one of the most common atypical pneumonia in pediatrics. In recent years, the incidence of MPP is high and the number of severe cases is increasing,such as severe MPP and refractory MPP, so early diagnosis and identification of severe cases is particularly important for clinical treatment. IL-6 and TNF-α are inflammatory cytokines, D-Dimer is a degradation product of fibrin. Studies have shown that the serum IL-6, TNF-α, D-Dimer increased of MPP children, and the severity are higher than the mild, which suggesting that the above indicators have a positive effect on the severity of MPP and they can be used as early identification of severe cases and prognosis of the reference indicators. In this paper, we reviewed the status and significances of IL-6, TNF-α and D-Dimer in children with MPP in recent years, and laid the foundation for the early diagnosis of severe cases of MPP and the related research.
作者
许钰翎
贺金娥
高春燕
XU Yuling;HE Jine;GAO Chunyan(Affiliated Hospital of Yan ' an University, Yan ' an Shanxi 716000, China;Department of Pediatrics, Affiliated Hospital of Yan ' an University, Yan ' an Shanxi 716000, China)
出处
《转化医学杂志》
2018年第6期373-376,共4页
Translational Medicine Journal
基金
延安市科技惠民计划项目(2016-HM-08-01)
