摘要
目的探讨抗血管内皮生长因子(VEGF)药物治疗湿性老年性黄斑变性(wAMD)患者的远期预后及其影响因素。方法回顾性分析56例(65眼)接受玻璃体腔注射抗VEGF药物(康柏西普)治疗的wAMD患者的临床资料。所有患者均随访2年,根据患者的裸眼视力改善情况,将患者分为有效组和无效组。比较两组患者的临床资料,并采用多因素Logistic回归模型分析影响患者远期视力的因素。结果56例(65眼)wAMD患者中,32例(34眼)患者(57.14%)视力较治疗前提高。两组患者的病程、治疗后1 d的睡眠状况自评量表(SRSS)评分、合并高血压比例、合并冠心病比例、吸烟史比较,差异有统计学意义(P<0.05)。多因素Logistic回归分析结果显示,病程、治疗后1 d的SRSS评分、合并高血压情况是wAMD患者抗VEGF药物治疗后远期视力的影响因素(P<0.05)。结论抗VEGF药物治疗可一定程度上改善wAMD患者的远期视力,病程、治疗后1 d的SRSS评分及合并高血压情况是wAMD患者抗VEGF药物治疗后远期视力的影响因素。
Objective To explore the long-term prognosis of anti-vascular endothelial growth factor(VEGF)drug for the treatment of patients with wet age-related macular degeneration(wAMD)and its influencing factors.Methods The clinical data of 56 patients(65 eyes)with wAMD who received intravitreal injection of anti-VEGF drug(conbercept)were retrospectively analyzed.All patients were followed up for 2 years,according to the improvement of naked eye visual acuity in patients,patients were divided into effective group or ineffective group.The clinical data were compared between patients of the two groups.The factors affecting patients′long-term visual acuity were analyzed by the multivariate Logistic regression model.Results Among 56 wAMD patients(65 eyes),the visual acuity of 32 cases(34 eyes)of patients(57.14%)was improved as compared with before treatment.There were statistically significant differences in disease course,the Self-Rating Scale of Sleep(SRSS)score after 1 day of treatment,and proportions of concomitant hypertension,concomitant coronary heart disease,as well as smoking history between the two groups(P<0.05).The results of multivariate Logistic regression analysis revealed that disease course,SRSS score after 1 day of treatment,and concomitant hypertension were the influencing factors for long-term visual acuity of wAMD patients after anti-VEGF drug therapy(P<0.05).Conclusion Anti-VEGF drug therapy can ameliorate long-term visual acuity of wAMD patients to a certain extent.Disease course,SRSS score after 1 day of treatment,and concomitant hypertension are the influencing factors for long-term visual acuity of wAMD patients after anti-VEGF drug therapy.
作者
罗海燕
文美丹
陶苗苗
刘琼
陶玲
LUO Haiyan;WEN Meidan;TAO Miaomiao;LIU Qiong;TAO Ling(Department of Nursing,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin 541002,Guangxi,China;Department of Ophthalmology,Nanxishan Hospital of Guangxi Zhuang Autonomous Region,Guilin 541002,Guangxi,China)
出处
《广西医学》
CAS
2023年第20期2452-2455,共4页
Guangxi Medical Journal
基金
广西壮族自治区卫生健康委员会自筹经费科研课题(Z20190734,Z20201408)。
关键词
湿性老年性黄斑变性
血管内皮生长因子
视力
远期疗效
影响因素
Wet age-related macular degeneration
Vascular endothelial growth factor
Visual acuity
Long-term efficacy
Influencing factors
