摘要
目的分析益肺养阴方加减联合常规西医治疗对肺结核伴2型糖尿病患者的疗效。方法选取2021.01-2021.12本院收治的肺结核伴2型糖尿病患者总共80例进行研究,经随机分组法分成对照组(西医常规治疗)和观察组(在对照组基础上开展益肺养阴方加减治疗)各有40例,观察两组基线资料、治疗前和治疗6个月后的空腹血糖、餐后2h血糖及糖化血红蛋白水平;治疗6个月后的痰菌转阴率及空洞闭合率;治疗前和治疗6个月后的外周血CD4+、CD8+、CD4+/CD8+、CD3+水平;不良反应出现情况。结果治疗前,两组空腹血糖、餐后2h血糖、糖化血红蛋白相比无显著差异(P>0.05);治疗后,观察组空腹血糖、餐后2h血糖、糖化血红蛋白均低于对照组(P<0.05)。观察组治疗后的痰菌转阴率及空洞闭合率高于对照组(P<0.05)。治疗前,两组CD4+、CD8+、CD3+及CD4+/CD8+相比无显著差异(P>0.05);治疗后,观察组CD4+、CD3+及CD4+/CD8+高于对照组(P<0.05),CD8+低于对照组(P<0.05)。两组用药期间肝功能受损、过敏性皮炎、视神经炎以及胃肠道反应等出现相比无显著差异(P>0.05)。结论益肺养阴方加减联合常规西医治疗对肺结核伴2型糖尿病患者疗效理想,能控制其血糖水平,降低其痰菌转阴率及空洞闭合率,改善其免疫功能,且安全性较高,值得采用。
Objective To analyze the clinical effectiveness of modified Yifei Yangyin prescriptions and western medicine in treating the pulmonary tuberculosis with type 2 diabetes mellitus.Methods 80 pulmonary tuberculosis patients with type 2 diabetes mellitus treated from January 2021 to December 2021 in our hospital were investigated.According to random grouping method,patients were divided into control group(n=40,western medicine)and observation group(n=40,modified Yifei Yangyin prescriptions and western medicine).Treatment outcomes were evaluated through the baseline data,fasting blood glucose,2-hour postprandial plasma glucose and glycosylated hemoglobin,sputum bacteria negative conversion ratio and cavity closure rates,peripheral blood CD4+,CD8+,CD4+/CD8+and CD3+levels after 6m of treatment as well as the adverse drug reactions.Results Before treatment,there were no significant between-group differences about the fasting blood glucose,2-hour postprandial plasma glucose and glycosylated hemoglobin contents(P<0.05);after treatment,the fasting blood glucose,2-hour postprandial plasma glucose and glycosylated hemoglobin contents in the observation group were significantly lower than those in the control group(P>0.05);the sputum bacteria negative conversion ratio and cavity closure rates in the observation group were significantly higher than those in the control group(P<0.05);before treatment,there were no significant between-group differences about CD4+,CD8+,CD3+and CD4+/CD8+values(P<0.05);after treatment,CD4+,CD3+and CD4+/CD8+values in the observation group were significantly higher than those in the control group(P>0.05);CD8+values in the observation group were significantly lower than those in the control group(P<0.05);during treatment,there were no significant between-group differences about the adverse reactions like the impaired liver function,allergic dermatitis,optic neuritis and gastrointestinal reactions(P>0.05).Conclusion The modified Yifei Yangyin prescriptions and western medicine can control the blood gluc
作者
贺仕伟
黄丹
彭金霞
陆慧
HE Shi-wei;HUANG Dan;PENG Jin-xia;LU Hui(Second Department of Internal Medicine,Luxi County Hospital of Traditional Chinese Medicine,Luxi 337022,Jiangxi Province,China;Department of Child Health Care,Luxi County Hospital of Traditional Chinese Medicine,Luxi 337022,Jiangxi Province,China;Department of Pulmonary Diseases,Luxi County Hospital of Traditional Chinese Medicine,Luxi 337022,Jiangxi Province,China;Acupuncture and Rehabilitation Department,Luxi County Hospital of Traditional Chinese Medicine,Luxi 337022,Jiangxi Province,China)
出处
《罕少疾病杂志》
2024年第1期44-47,共4页
Journal of Rare and Uncommon Diseases
基金
江西省卫生健康委科技计划项目(202312204)。
关键词
益肺养阴方
西医常规治疗
肺结核
2型糖尿病
免疫功能
不良反应
Modified Yifei Yangyin Prescriptions
Western Medicine
Pulmonary Tuberculosis
Type 2 Diabetes Mellitus
Immune Function
Adverse Reactions