摘要
目的探讨全腔镜食管癌根治术对老年食管癌患者的治疗效果。方法根据治疗方式的不同将108例老年食管癌患者分为对照组(n=58,常规开胸食管癌根治术)和全腔镜组(n=50,全腔镜食管癌根治术)。比较两组患者的肺功能指标[肺活量(VC)、最大通气量(MVV)、第1秒用力呼气容积(FEV_(1))]、炎性因子[降钙素原(PCT)、C反应蛋白(CRP)、白细胞介素-6(IL-6)]水平、免疫功能指标[免疫球蛋白A(IgA)、免疫球蛋白G(IgG)]、疼痛程度[视觉模拟评分法(VAS)]、睁眼时间、拔管时间。结果治疗后,两组患者VC、MVV、FEV_(1)均低于本组治疗前,全腔镜组患者VC、MVV、FEV_(1)均高于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者PCT、CRP、IL-6水平均低于本组治疗前,全腔镜组患者PCT、CRP、IL-6水平均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组患者IgA、IgG水平均高于本组治疗前,全腔镜组患者IgA、IgG水平均高于对照组,差异均有统计学意义(P<0.05)。全腔镜组患者的VAS评分明显低于对照组,睁眼时间、拔管时间均明显短于对照组,差异均有统计学意义(P<0.01)。结论全腔镜食管癌根治术治疗老年食管癌患者,可改善肺功能和免疫功能,降低炎性因子水平和疼痛程度,促进患者恢复。
Objective To investigate the therapeutic effect of total laparoscopic radical esophagectomy in elderly pa-tients with esophageal cancer.Method A total of 108 elderly patients with esophageal cancer were divided into control group(n=58,conventional thoracotomy radical esophagectomy)and total laparoscopic group(n=50,total laparoscopic radical esophagectomy)according to different treatment methods.The pulmonary function indicators[vital capacity(VC),maximal voluntary ventilation(MVV),forced expiratory volume in one second(FEV_(1))],inflammatory factors[pro-calcitonin(PCT),C-reactive protein(CRP),interleukin-6(IL-6)]levels,immune function indicators[immunoglobulin A(IgA),immunoglobulin G(IgG)],pain degree[visual analogue scale(VAS)],eye-opening time,and extubation time of the two groups were compared.Result After treatment,the VC,MVV,and FEV_(1) of the two groups were lower than those before the treatment,and the VC,MVV,and FEV_(1) in the total laparoscopic group were higher than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the levels of PCT,CRP,and IL-6 in the two groups were lower than those before treatment,the levels of PCT,CRP,and IL-6 in the total endoscopic group were lower than those in the control group,and the differences were statistically significant(P<0.05).After treatment,the IgA and IgG levels of the two groups were higher than those before treatment,and the IgA and IgG levels in the total laparoscopic group were higher than those in the control group,and the differences were statistically significant(P<0.05).The VAS score in the total endoscopic group was significantly lower than that in the control group,and the eye-opening time and extubation time were significantly shorter than those in the control group,and the differences were statistically significant(P<0.01).Conclusion Total laparoscopic radical esophagectomy for elderly patients with esophageal cancer could improve the patient's lung function and immune function,reduce the level of infla
作者
范俊利
陈强
吴晓鹏
FAN Junli;CHEN Qiang;WU Xiaopeng(Department of Esophageal Cancer Surgery,the First Affiliated Hospital of He'nan University of Science and Technology,Luoyang 471003,He'nan,China)
出处
《癌症进展》
2023年第21期2384-2386,2407,共4页
Oncology Progress
基金
河南省省级科技研发计划联合基金项目(222103810050)。
关键词
全腔镜食管癌根治术
食管癌
肺功能指标
免疫功能指标
total laparoscopic radical esophagectomy
esophageal cancer
lung function indicator
immune function indicator
