摘要
目的分析艾司氯胺酮复合瑞马唑仑在老年患者全身麻醉诱导中应用对药物不良反应与麻醉效果的影响。方法选取2020年1月—2023年1月江苏省常州市武进人民医院接诊的112例老年患者为研究对象,按照随机数表法分为两组,每组56例。对照组麻醉诱导应用咪达唑仑复合丙泊酚,观察组应用艾司氯胺酮复合瑞马唑仑,分析两组患者应用效果及药物不良反应发生情况。结果观察组苏醒时间(13.30±2.35)min、拔管时间(17.54±1.46)min短于对照组,Ricker镇静-躁动评分(3.37±0.45)分低于对照组,差异有统计学意义(t=3.838、5.742、15.403,P<0.05)。观察组诱导期间低血压发生率(3.57%)明显低于对照组,差异有统计学意义(χ^(2)=4.940,P<0.05)。插管前,观察组舒张压(73.78±3.11)mmHg、收缩压(110.87±4.54)mmHg高于对照组,差异有统计学意义(t=7.850、9.190,P<0.05);插管后3 min,观察组舒张压(80.97±3.52)mmHg、收缩压(127.78±5.46)mmHg高于对照组,差异有统计学意义(t=7.021、10.399,P<0.05)。结论艾司氯胺酮复合瑞马唑仑在老年患者全身麻醉诱导中应用可有效缩短苏醒时间、拔管时间,平稳血压,减少低血压事件发生。
Objective To analyze the effects of esketamine combined with remimazolam on the adverse drug reactions and anesthetic effects in the induction of general anesthesia in elderly patients.Methods A total of 112 elderly patients admitted to Wujin People's Hospital from January 2020 to January 2023 were selected as the study objects and divided into two groups according to random number table method,with 56 cases in each group.The control group was treated midazolam combined with propofol,and the observation group was treated esketamine combined with remimazolam.The application effect and adverse drug reaction of the two groups were analyzed.Results The recovery time(13.30±2.35)min and extubation time(17.54±1.46)min in the observation group were shorter than those in the control group,and the Ricker sedation-agitation score(3.37±0.45)points was lower than that in the control group,and the difference was statistically significant(t=3.838,5.742,15.403,P<0.05).The incidence of hypotension during induction in observation group(3.57%)was significantly lower than that in control group,and the difference was statistically significant(χ^(2)=4.940,P<0.05).Before intubation,diastolic blood pressure(73.78±3.11)mmHg and systolic blood pressure(110.87±4.54)mmHg in observation group were higher than those in control group,and the differences were statistically significant(t=7.850,9.190,P<0.05).After intubation 3 min,diastolic blood pressure(80.97±3.52)mmHg and systolic blood pressure(127.78±5.46)mmHg in the observation group were higher than those in the control group,and the differences were statistically significant(t=7.021,10.399,P<0.05).Conclusion Esketamine combined with remimazolam in the induction of general anesthesia in elderly patients can effectively shorten the wake time,extubation time,stabilize blood pressure and reduce the occurrence of hypotensive events.
作者
邹志伟
王硕
王玉凯
ZOU Zhiwei;WANG Shuo;WANG Yukai(Department of Anesthesiology,Wujin People's Hospital,Changzhou,Jiangsu Province,213000 China)
出处
《系统医学》
2023年第19期49-52,共4页
Systems Medicine
关键词
艾司氯胺酮
瑞马唑仑
全身麻醉
麻醉诱导
Esketamine
Remimazolam
General anesthesia
Induction of anesthesia
