摘要
目的:研究依达拉奉右莰醇联合阿托伐他汀对老年急性脑梗死伴颈动脉狭窄患者血液流变学和血脂水平的影响。方法:选取2021年3月~2023年4月某院收治的急性脑梗死伴颈动脉狭窄老年患者80例作为研究对象。采用住院号奇偶数法分为对照组(39例)和观察组(41例)。对照组于常规对症治疗基础上给予阿托伐他汀治疗,观察组于对照组基础上给予依达拉奉右莰醇治疗。比较两组患者血液流变学水平、血脂水平、血清脂蛋白相关磷脂酶A2(LP-PLA2)、同型半胱氨酸(Hcy)、缺血修饰白蛋白(IMA)、美国国立卫生研究院脑卒中量表(NIHSS)评分、日常生活活动(ADL)评分,以及不良反应发生情况。结果:治疗后,两组患者纤维蛋白原(FIB)、红细胞压积(HCT)均降低,且观察组低于对照组(P<0.05);活化部分凝血活酶时间(APTT)升高,且观察组高于对照组(P<0.05);总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)及甘油三酯(TG)水平降低,且观察组低于对照组(P<0.05);高密度脂蛋白胆固醇(HDL-C)上升,且观察组高于对照组(P<0.05)。观察组血清LP-PLA2、Hcy和IMA水平低于对照组(P<0.05);NIHSS评分低于对照组(P<0.05);ADL评分高于对照组(P<0.05)。两组患者恶心呕吐、皮疹、头晕、关节痛等不良反应总发生率比较无统计学差异(P>0.05)。结论:与单用阿托伐他汀相比,依达拉奉右莰醇联合阿托伐他汀治疗老年急性脑梗死伴颈动脉狭窄患者,能更好地改善患者血液流变学、血脂水平,降低患者血清LP-PLA2、Hcy和患者IMA水平,且安全性较高。
Objective:To investigate the effect of edaravone dexborneol combined with atorvastatin on hemorheology and blood lipid levels in elderly patients with acute cerebral infarction and carotid artery stenosis.Methods:A total of 80 elderly patients with acute cerebral infarction and carotid artery stenosis who were treated in a hospital between March 2021 and April 2023 were selected as the study subjects.The patients were divided into control group(39 patients)and observation group(41 patients)by odd-even number method of hospitalization number.The control group was treated with atorvastatin on the basis of conventional symptomatic treatment,and the observation group was treated with edaravone dexborneol on the basis of the control group.The hemorheology level,blood lipid level,lipoprotein-associated phospholipase A2(LP-PLA2),homocysteine(Hcy),ischemia modified albumin(IMA),National Institutes of Health Stroke Scale(NIHSS)score,activities of daily living(ADL)score,and the occurrence of adverse reactions were compared between the two groups.Results:After treatment,fibrinogen(FIB)and haematocrit(HCT)were decreased in both groups,and observation group was lower than control group(P<0.05).The activated partial thromboplastin time(APTT)in observation group was higher than that in control group(P<0.05).The levels of total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and triglyceride(TG)were decreased,and the observation group was lower than the control group(P<0.05).High density lipoprotein cholesterol(HDL-C)was increased,and observation group was higher than control group(P<0.05).The levels of LP-PLA2,Hcy and IMA in observation group were lower than those in control group(P<0.05).The NIHSS score of observation group was lower than that of control group(P<0.05).The ADL score in observation group was higher than that in control group(P<0.05).There was no significant difference in the total incidence of nausea and vomiting,rash,dizziness and arthralgia between the two groups(P>0.05).Conclusion:Compared with ator
作者
秦晋辉
程相杰
朱星阳
王晓丽
宋元贞
胡义平
张青
赵茜
QIN Jin-hui;CHENG Xiang-jie;ZHU Xing-yang;WANG Xiao-li;SONG Yuan-zhen;HU Yi-ping;ZHANG Qing;ZHAO Qian(Nanyang Second General Hospital,Nanyang 473000,China)
出处
《中国合理用药探索》
CAS
2023年第12期86-92,共7页
Chinese Journal of Rational Drug Use
基金
南阳市科技攻关计划项目(KJGG019)。
