摘要
异种器官移植有望用于解决临床移植的器官供需失衡问题。猪具有的天然优势使其比非人灵长类动物更适合作为移植器官的供体。而猪器官移植后出现的一系列生物学障碍已被人们通过基因工程和药物抑制等手段克服。同时,基因工程技术的日渐成熟显著优化了异种移植适用猪的构建方案,推动了猪器官移植研究的发展。尽管猪器官异种移植真正进入临床实验阶段尚需时日,但近年来在少数脑死亡或重症患者身上进行的猪器官移植实验已展现出猪器官异种移植在解决临床移植器官供需失衡问题上的巨大应用前景。
Xenotransplantation holds the promise of being used to address the imbalance between organ supply and demand for clinical transplantation.Pigs have natural features that make them more suitable donors for transplant organs than non-human primates.A series of biological barriers that arise after pig organ transplantation have been overcome by genetic engineering and pharmacological suppression.Meanwhile,the gradual maturity of the genetic engineering technology has been significantly optimized for suitable pigs for xenotransplantation,and promoted the development of pig organ transplantation research.Although it will take time for pig organ xenotransplantation to enter the clinical trial stage,recent studies conducted in a few brain-dead or critically ill patients have exhibited the great potential of porcine xenotransplantation in solving the imbalance between supply and demand of organs for clinical transplantation.
作者
刘雪莉
胡雪峰
LIU Xue-Li;HU Xue-Feng(School of Life Sciences,Fujian Normal University,Fujian Key Laboratory of Development and Neurobiology,Fuzhou 350117,China)
出处
《中国生物化学与分子生物学报》
CAS
CSCD
北大核心
2023年第11期1562-1568,共7页
Chinese Journal of Biochemistry and Molecular Biology
基金
国家自然科学基金项目(No.81771034)资助。
关键词
异种器官移植
免疫排斥
转基因猪
基因工程技术
xenotransplantation
immunological rejection
genetically modified pigs
genetic engineering technology
