摘要
结直肠癌是胃肠道中常见的恶性肿瘤,其发生发展除了与自身特性相关外,也与肿瘤所处的微环境相关。肿瘤相关巨噬细胞(TAM)作为肿瘤微环境(TME)中数量最多的免疫细胞之一,被募集到肿瘤部位后,受到TME中不同的信号刺激可分化为M1和M2两种不同亚型。结直肠癌早期TAM主要表现为M1型巨噬细胞,介导抑制肿瘤生长的免疫反应;在晚期阶段,TAM逐渐以M2型巨噬细胞为主,表现出免疫抑制、刺激肿瘤细胞增殖和肿瘤血管生成、促进肿瘤细胞侵袭及转移等能力。研究发现影响TAM极化可以调控其与结直肠癌发生发展的关系。
Colorectal cancer is a common malignant tumor in gastrointestinal tract.Its onset and development are associated with its own characteristics as well as the tumor microenvironment(TME)in which tumor-associated macrophages(TAMs)are the most abundant immune cells.After being recruited to the tumor site and stimulated by different signals in TME,TAMs can grow into two different subtypes,namely M1 and M2.TAMs are mainly manifested as M1 macrophages in the early stage of colorectal cancer,mediating the immune response to inhibit tumor growth.In the late stage,TAMs mainly grow into M2 macrophages,showing the ability to suppress immunity,stimulate the proliferation of tumor cells and tumor angiogenesis,and promote the invasion and metastasis of tumor cells.It has been found that intervention in TAMs polarization can regulate its relationship with the onset and development of colorectal cancer.
作者
黄胜男
李芳芳
金丹
HUANG Shengnan;LI Fangfang;JIN Dan(Department of Immunology and Pathogenic Biology,College of Medicine,Yanbian University,Yanji 133002,China)
出处
《细胞与分子免疫学杂志》
CAS
CSCD
北大核心
2023年第10期940-945,共6页
Chinese Journal of Cellular and Molecular Immunology
基金
国家自然科学基金(81860288)
吉林省教育厅课题(JJKH20210591KJ)。
关键词
结直肠癌
肿瘤相关巨噬细胞
肿瘤微环境
综述
colorectal cancer
tumor-associated macrophages(TAMs)
tumor microenvironment(TME)
review
