摘要
目的评价舒筋活血汤联合双氯芬酸钠治疗下肢急性软组织损伤(ASTI)的临床疗效及对炎症因子和组织修复因子的影响。方法将120例ASTI患者随机分为对照组与观察组各60例。对照组给予双氯芬酸钠凝胶量外用;观察组在对照组基础上口服舒筋活血汤,每日1剂。两组连续治疗14 d。应急用药为塞来昔布胶囊,视觉模拟量表(VAS)评分≥7分时服用1粒(200 mg)。于治疗前、治疗后3、7、10、14 d比较VAS评分;治疗前后进行气滞血瘀证证候评分;记录疼痛和肿胀消失时间;测定治疗前后肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、前列腺素E2(PGE2)、碱性细胞生长因子(bFGF)和人表皮生长因子(EGF)水平;进行安全性评价。比较两组临床疗效。结果治疗后,两组患者VAS评分下降,观察组在治疗后3、7、10、14 d的VAS评分均低于对照组(P<0.05);治疗后观察组各主要症状评分和气滞血瘀证证候总分低于对照组(P<0.05);观察组疼痛、肿胀消失时间短于对照组(P<0.05),观察组止痛药物用量少于对照组(P<0.05);观察组TNF-α、IL-1β和PGE2水平低于对照组(P<0.05);观察组bFGF和EGF高于对照组(P<0.05);治疗后,观察组临床疗效总有效率为91.67%,高于对照组的75.00%(P<0.05)。结论舒筋活血汤联合双氯芬酸钠治疗下肢ASTI能降低炎性因子水平、升高组织修复因子水平,减轻临床症状,缩短病程,提高疗效,且临床使用安全。
Objective:To evaluate the clinical efficacy of Shujin Huoxue Decoction combined with diclofenac so⁃dium in the treatment of acute soft tissue injury(ASTI)of the lower limbs and its impact on inflammatory factors and tissue repair factors.Methods:A total of 120 ASTI patients were randomly divided into the control group and observation group,with 60 cases in each group.The control group was given diclofenac sodium gel,appropri⁃ate for external use,and on the basis of the control group,the observation group was orally treated with Shujin Huoxue Decoction,one dose per day.Both groups were treated continuously for 14 days.The emergency medication was celecoxib capsules,and given 1 capsule(200 mg)when the VAS scores≥7.The VAS scores before and 3,7,10,and 14 days after treatment,score of Qi stagnation and blood stasis syndrome before and after treatment were compared;the time when pain and swelling disappear were recorded;the tumor necrosis factor(TNF-α)before and after treatment,Interleukin-1β(IL-1β),the levels of prostaglandin E2(PGE2),basic cell growth factor(bFGF),and human epidermal growth factor(EGF)were detected;the safety evaluation and the clinical efficacy of two groups were compared.Results:After treatment,the VAS scores of the two groups of patients gradually decreased,and the VAS scores of the observation group were lower than those of the control group on days 3,7,10,and 14 af⁃ter treatment(P<0.05);after treatment,the main symptom scores and total score of Qi stagnation and blood stasis syndrome in the observation group were lower than those of the control group(P<0.05);the disappearance time of pain and swelling in the observation group was shorter than those in the control group(P<0.05),and the dosage of painkillers taken in the observation group was lower than those in the control group(P<0.05);the TNF-α,IL-1β,PGE2 in the observation group were lower than those of the control group(P<0.05);the bFGF and EGF in the ob⁃servation group were higher than those in the control group(P<0.05);after
作者
张亮
徐亚伟
徐坤鹏
Zhang Liang;Xu Yawei;Xu Kunpeng(Qingdao Eighth People′s Hospital,Shandong,Qingdao 266000,China)
出处
《中国中医急症》
2023年第12期2167-2170,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
山东省中医药科技面上项目(M-2022268T)。
关键词
急性软组织损伤
气滞血瘀证
舒筋活血汤
双氯芬酸钠
炎症因子
碱性细胞生长因子
人表皮生长因子
Acute soft tissue injury
Qi stagnation and blood stasis syndrome
Shujin Huoxue Decoction
Diclofe⁃nac sodium
Inflammatory factors
Alkaline cell growth factor
Human epidermal growth factor
