摘要
目的优化消化复宁汤的提取工艺参数。方法以指纹图谱相似指数(C、A)、多指标成分总含量和浸膏得率为指标,采用中心组合设计-响应面法(RSCCD)优化消化复宁汤提取工艺参数。结果提取次数对综合评分值具有显著性影响,最佳提取工艺参数为加9倍量水、煎煮1.5 h、提取3次。该条件下综合评分值的预测值为100.333,验证均值为96.75,与预测值差异无统计学意义。结论该文所确定的消化复宁汤的提取工艺方法科学合理、稳定可行,为后期制剂的研究与开发奠定基础。
Objective To optimize the extraction process parameters of digestive Funing decoction.Methods Taking fingerprint similarity index(C,A),the total content of multiple components and extract yield as indexes,the extraction process parameters of Xiaohua Funing Tang were optimized by central composite design response surface methodology(RSCCD).Results The extraction times had a significant effect on the comprehensive score.The optimum extraction parameters were adding 9 times of water,decocting for 1.5 hour and extracting for 3 times.Under this condition,the predicted value of the comprehensive score was 100.333,and the verified mean value was 96.75,which was not significantly different from the predicted value.Conclusion The extraction process of Xiaohua Funing Tang determined in this paper is scientific,reasonable,stable and feasible.It lays a foundation for the research and development of later preparations.
作者
陈莉
王盛
张迪
程蕤
汪永忠
CHEN Li;WANG Sheng;ZHANG Di;CHENG Rui;WANG Yongzhong(The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine,Hefei 230031,China;Anhui University of Chinese Medicine,Hefei 230031,China)
出处
《医药导报》
CAS
北大核心
2023年第12期1813-1818,共6页
Herald of Medicine
基金
安徽省高等学校自然科学研究项目(KJ2020A0409)
安徽中医药大学第一附属医院临床科学研究重点项目(2020yfyzc07)
全国中医药特色技术传承人才培训项目(T20184828005)。
关键词
消化复宁汤
提取工艺
中心组合响应面
多指标成分测定的指纹图谱
相似指数
Xiaohua Funing Tang
Extraction process
Central combined response surface
Fingerprint
Similarity index C
Similarity index A
