摘要
目的 分析血清可溶性尿激酶型纤溶酶原激活物受体(suPAR)、血红蛋白(Hb)及乳酸脱氢酶(LDH)表达在多发性骨髓瘤(MM)患者预后评估中的作用。方法 选取2017年4月至2022年7月安徽医科大学附属滁州医院收治的MM患者53例为研究对象(MM组),另选取本院同期治疗的非血液肿瘤患者49例(IDA 29例,MA 20例)作为对照组。对比两组血清suPAR、Hb及LDH的表达水平;对比MM组不同分期血清suPAR、Hb及LDH表达水平;分析影响MM患者预后的单因素,采用logistic回归模型分析影响MM患者预后的相关因素。结果 MM组suPAR、LDH表达高于对照组,Hb低于对照组,差异具有统计学意义(P<0.05)。suPAR、LDH表达:Ⅰ期<Ⅱ期<Ⅲ期;Hb表达:Ⅰ期>Ⅱ期>Ⅲ期,差异具有统计学意义(P<0.05)。经随访发现,预后良好组38例,预后不良组15例。两组年龄、性别、临床分型、肌酐、纤维蛋白原比较差异无统计学意义(P>0.05)。两组分期、suPAR、Hb及LDH表达比较差异具有统计学意义(P<0.05)。logistic回归分析显示:分期、suPAR、Hb及LDH表达为影响MM患者预后不良的危险因素(P<0.05)。结论 血清suPAR、Hb及LDH在MM患者中呈异常表达,三者在监测患者病情进展及评估预后情况具有重要临床价值。
Objective To analyze the role of serum soluble urokinase-type plasminogen activator receptor(suPAR),hemoglobin(Hb)and lactate dehydrogenase(LDH)expression in the prognosis assess-ment of multiple myeloma(MM)patients.Methods Fifty-three patients with MM admitted to Chuzhou Hos-pital of Anhui Medical University from April 2017 to July 2022 were selected as the study object(MM group),and 49 patients with non-hematologic tumors(IDA 29 and MA 20)treated in our hospital during the same period were selected as the control group.The expression levels of suPAR,Hb and LDH in serum of the two groups were compared.The expression levels of suPAR,Hb and LDH in different stages of the MM group were compared.The single factors influencing the prognosis of MM patients were analyzed,and the related fac-tors influencing the prognosis of MM patients were analyzed by logistic regression model.Results The ex-pressions of suPAR and LDH in the MM group were higher than those in the control group,and Hb in the MM group was lower than that in the control group,the difference was statistically significant(P<0.05).The ex-pression of suPAR and LDH:stageⅠ<stageⅡ<stageⅢ;the expression of Hb:stageⅠ>stageⅡ>stageⅢ,the difference was statistically significant(P<0.05).The follow-up found 38 cases in the good prognosis group and 15 cases in the poor prognosis group.There was no significant difference in age,gender,clinical type,creatinine,and fibrinogen between the two groups(P>0.05).There were statistically significant differences in stage,suPAR,Hb and LDH expressions between the two groups(P<0.05).Logistic regression analysis showed that stage,suPAR,Hb and LDH expression were risk factors for poor prognosis in MM patients(P<0.05).Conclusion Serum suPAR,Hb and LDH are abnormally expressed in MM patients,which have im-portant clinical value in monitoring the progression of patientsdisease and evaluating the prognosis.
作者
徐士云
鲍文强
金其川
凌春
XU Shiyun;BAO Wenqiang;JIN Qichuan;LING Chun(Department of Hematology,Chuzhou Hospital Affiliated to Anhui Medical University(Chuzhou First Peoples Hospital),Chuzhou,Anhui,China,239000)
出处
《分子诊断与治疗杂志》
2023年第11期1899-1902,共4页
Journal of Molecular Diagnostics and Therapy
基金
安徽医科大学校科研基金立项资助项目(2020xkj082)。
