摘要
目的:探讨法莫替丁三联疗法对急性上消化道出血(AUGB)患者血尿素氮/肌酐(BUN/Cr)及前列腺素E_(2)(PGE_(2))的影响。方法:选取2019年3月—2022年5月宜黄县人民医院收治的急性上消化道出血患者80例,根据电脑随机分配法分为对照组40例与研究组40例。两组均接受常规治疗,在此基础上,对照组给予凝血酶、生长抑素治疗,研究组给予法莫替丁、凝血酶、生长抑素三联药物治疗。比较两组止血效果、临床相关指标[BUN/Cr、PGE_(2)、血钾(K^(+))]、凝血功能[凝血酶时间(TT)、凝血酶原时间(PT)、纤维蛋白原(FIB)]和不良反应发生率。结果:研究组止血总有效率为97.50%,高于对照组的85.00%(P<0.05)。治疗后两组BUN/Cr值、K^(+)、TT、PT水平较治疗前均下降,且研究组均优于对照组,PGE_(2)、FIB水平均上升,且研究组均高于对照组(P<0.05)。两组不良反应发生率比较差异无统计学意义(P>0.05)。结论:法莫替丁三联疗法应用于AUGB患者能有效提升止血效果,可降低患者体内的BUN/Cr值及PGE_(2)水平,改善凝血功能,安全性可靠。
Objective:To investigate the effects of Famotidine triple therapy on blood urea nitrogen/creatinine(BUN/Cr)and prostaglandin E_(2)(PGE_(2))in patients with acute upper gastrointestinal bleeding(AUGB).Method:A total of 80 patients with acute upper gastrointestinal bleeding admitted to Yihuang County People's Hospital from March 2019 to May 2022 were selected and divided into control group(40 cases)and study group(40 cases)according to computer random allocation method.Both groups received conventional treatment,on that basis,the control group was given Thrombin and Somatostatin treatment,and the study group was given Famotidine,Thrombin and Somatostatin triple therapy.Hemostatic effect,clinical related indexes[BUN/Cr,PGE_(2),blood potassium(K^(+))],coagulation function[thrombin time(TT),prothrombin time(PT),fibrinogen(FIB)]and adverse reaction rate of the two groups were compared.Result:The total effective rate of hemostasis in the study group was 97.50%,which was higher than 85.00%in the control group(P<0.05).After treatment,BUN/Cr value,K^(+),TT,PT levels in two groups were decreased compared with before treatment,and the study group were better than those of the control group,PGE_(2),FIB levels were increased,and the study group were higher than those of the control group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The application of Famotidine triple therapy in the treatment of AUGB patients can effectively improve the hemostatic effect,reduce the BUN/Cr value and PGE_(2)level in patients,improve coagulation function,safe and reliable.
作者
吴国荣
杨发春
WU Guorong;YANG Fachun(Yihuang County People's Hospital,Jiangxi Province,Yihuang 344400,China;不详)
出处
《中国医学创新》
CAS
2023年第32期32-35,共4页
Medical Innovation of China
关键词
急性上消化道出血
法莫替丁三联疗法
尿素氮/肌酐
前列腺素E_(2)
凝血功能
Acute upper gastrointestinal bleeding
Famotidine triple therapy
Blood urea nitrogen/creatinine
Prostaglandin E_(2)
Coagulation function
