摘要
目的探讨定量药理学和药物经济学(PMPE)联合模型在药物生命周期中的应用。方法在PubMed、EMBASE以及the Cochrane Library数据库检索PMPE联合模型在药物研发中的应用。结果共获取12篇文献,报道了PMPE联合模型在药物早期研发决策、临床试验设计优化,药品合理定价等药物研发阶段的应用,以及在药物上市后仿制药的上市决策和临床精准用药方面发挥的重要作用。结论PMPE联合模型有助于整个药物生命周期的经济学评价,为药物研发及药物资源的合理利用提供参考。
OBJECITVE To explore the application of the pharmacometrics-pharmacoeconomics(PMPE)model in the drug lifecycle.METHODS A systematic literature search of PubMed,EMBASE,and Cochrane Library databases for the application in drug research and development of PMPE model was conducted.RESULTS A total of 12 literatures were obtained,which reported the application of PMPE model in drug research and development stage,such as early-stage research and development decision,optimization of clinical trial design,and rational drug pricing,as well as the important role it plays in the post-market approval of generic drugs and clinical accurate drug.CONCLUSION The PMPE model is helpful to the development of economic evaluation in the entire drug lifecycle,which may provide a reference for the development of drug and the rational use of drug resources.
作者
陈蕊
柴青青
刘晓芹
焦正
CHEN Rui;CHAI Qingqing;LIU Xiaoqin;JIAO Zheng(Department of Pharmacy,Chest Affiliated Hospital Shanghai Jiao Tong University School of Medicine,Shanghai Chest Hospital,Shanghai 200030,China)
出处
《中国药学杂志》
CAS
CSCD
北大核心
2023年第19期1795-1800,共6页
Chinese Pharmaceutical Journal
关键词
定量药理学
药物经济学
药物研发
药品评价
模型
pharmacometrics
pharmacoeconomics
drug research and development
drug assessment,model
