摘要
目的研究国产阿卡波糖治疗2型糖尿病的经济效果。方法选择46例2型糖尿病患者,随机分为两组,治疗组22例,给予国产阿卡波糖胶囊50 mg,tid口服治疗;对照组24例,给予进口阿卡波糖片剂50 mg,tid口服治疗。治疗8周后,观察两组降空腹血糖(FBG)及餐后2 h血糖(2 hPBG)的疗效,并运用药物经济学理论进行回顾性分析。结果用药8周后,治疗组、对照组降空腹血糖的总有效率分别为81.82%、75.00%,降餐后2 h血糖的总有效率分别为86.36%、83.33%,两组间疗效比较差异无显著性(P>0.05)。治疗组、对照组成本分别为707.16元、801.80元。治疗组、对照组不良反应发生率分别为27.27%、54.17%,两组间比较有统计学差异(P<0.05)。结论治疗组效果好,成本低,不良反应少,值得临床推广使用。
Objective To study on pharmacoeconomics of homemade acarbose in management of type 2 diabetes mellitus, Method 46 patients with type 2 diabetes mellitus were randomly assigned two groups. Treatment group （22 cases） took homemade acarbose capsules orally （50 mg t. i. d）. Control group （24 cases） took imported acarbose tablets orally （50 mg t, i, d）, After 8 weeks,the level of Fasting and postprandial blood sugar were evaluated in two groups respectively. Pharmacoeconomics analysis was used retrospectively. Result In terms of fasting blood sugar, the effective rate in two group were 81.82% and 75.00% respectively,in terms of postprandial blood sugar, the effective rate were 86, 36% and 83.33% respectively. The rate in the two groups were not significantly different （ P 〉 0.05）. But the costs were 707.16 yuan in the treatment group and 801.80 yuan in the control group, and the ratio of adverse drug reactions were 27, 27% in the treatment group and 54.17% in control group. The costs and ratio of food adverse drug reaction were lower in treatment group than that in control group（P 〈 0,05）. Conclusion The homemade acarbose is more effective and lower cost and the ratio of adverse drug reactions.
出处
《广东药学》
2005年第6期42-44,共3页
Guangdong Pharmaceutical Journal
关键词
阿卡波糖
糖尿病
药物经济学
Acarbose
Diabetes mellitus
Pharmacoeconomics
