摘要
目的:探讨达格列净在2型糖尿病合并慢性肾脏病中的治疗效果。方法:选取2021年1月—2022年1月云南省滇南中心医院收治的106例2型糖尿病合并慢性肾脏病患者,使用随机数字表法将其分为观察组(n=53)及对照组(n=53)。对照组接受氯沙坦治疗,观察组在对照组基础上加用达格列净。对比两组治疗总有效率、肾功能指标、血糖水平及血管内皮功能指标。结果:观察组的治疗总有效率(94.34%)高于对照组(81.13%)(P<0.05)。治疗前,两组的血尿素氮(BUN)、血清肌酐(Scr)、尿白蛋白排泄率(UAER)、肾小球滤过率(GFR)及肌酐清除率(Ccr)水平比较,差异均无统计学意义(P>0.05);治疗后,两组的BUN、Scr及24 h UAER较治疗前均降低,且观察组均低于对照组(P<0.05);GFR及Ccr较治疗前均升高,且观察组均高于对照组(P<0.05)。治疗前,两组的空腹血糖(FPG)、餐后2 h血糖(2 h PG)、糖化血红蛋白(HbA1c)、血管紧张素Ⅱ(AngⅡ)、血管内皮生长因子(VEGF)、内皮素-1(ET-1)水平相比,差异均无统计学意义(P>0.05);治疗后,两组的上述指标较治疗前均降低,且观察组均低于对照组(P<0.05)。结论:达格列净联合氯沙坦可显著改善2型糖尿病合并慢性肾脏病患者的肾功能、降低血糖水平,优化血管内皮功能,效果显著。
Objective:To investigate the therapeutic effect of Dapagflozin in type 2 diabetes mellitus complicated with chronic kidney disease.Method:A total of one hundred and six patients with type 2 diabetes mellitus complicated with chronic kidney disease admitted to Southern Central Hospital of Yunnan Province from January 2021 to January 2022 were selected,and divided into observation group(n=53)and control group(n=53)using the random number table method.The control group was treated with Losartan,and the observation group was treated with Dapagflozin on the basis of the control group.The total effective rate of treatment,renal function indicators,blood glucose level and vascular endothelial function indicators of the two groups were compared.Result:The total effective rate of treatment in the observation group(94.34%)was higher than that in the control group(81.13%)(P<0.05).Before treatment,the levels of blood urea nitrogen(BUN),serum creatinine(Scr),urinary albumin excretion rate(UAER),glomerular filtration rate(GFR)and creatinine clearance rate(Ccr)were not significantly different between the two groups(P>0.05);after treatment,BUN,Scr and 24 h UAER in both groups were decreased compared with those before treatment,and those in the observation group were lower than those in the control group(P<0.05),the GFR and Ccr were both increased compared with those before treatment,and those in the observation group were higher than those in the control group(P<0.05).Before treatment,the levels of fasting plasma glucose(FPG),2 h postprandial blood glucose(2 h PG),glycosylated haemoglobin(HbA1c),angiotensinⅡ(AngⅡ),vascular endothelial growth factor(VEGF)and endothelin-1(ET-1)were not significantly different between the two groups(P>0.05);after treatment,all above indicators in both groups were reduced compared with those before treatment,and those in the observation group were lower than those in the control group(P<0.05).Conclusion:Dapagflozin combined with losartan can significantly improve renal function,reduce blood gluc
作者
戴彧君
曹芳
吉惠
佘艳军
DAI Yujun;CAO Fang;JI Hui;SHE Yanjun(Southern Central Hospital of Yunnan Province,Mengzi 661100,China;不详)
出处
《中国医学创新》
CAS
2023年第33期25-29,共5页
Medical Innovation of China
关键词
2型糖尿病合并慢性肾脏病
氯沙坦
达格列净
肾功能
Type 2 diabetes mellitus complicated with chronic kidney disease
Losartan
Dapagflozin
Renal function
