摘要
目的:回顾性分析芪地固肾方治疗糖尿病肾病(DN)蛋白尿的临床效果及安全性。方法:选取2019年1月至2022年1月该院脾肾气虚型DN患者80例,采用计算机随机分组方法分配,分为观察组和对照组,各40例。对照组患者采用常规西药治疗控制病情,观察组患者在对照组基础上口服芪地固肾方,持续治疗2个月。观察两组患者治疗8周后的临床疗效、尿β2-微球蛋白、24 h尿蛋白定量、血肌酐(Cr)和尿素氮(BUN)水平,以及在治疗过程中出现的不良反应。结果:治疗后,两组患者Cr、BUN、24 h尿蛋白定量、尿β2-微球蛋白水平均明显降低,差异均有统计学意义(P<0.05);与对照组相比,观察组患者Cr、BUN、24 h尿蛋白定量、尿β2-微球蛋白水平显著降低,差异均有统计学意义(P<0.05)。观察组患者的总有效率为65.0%(26/40),明显高于对照组的35.0%(14/40),差异有统计学意义(P<0.05)。观察组、对照组患者的不良反应发生率分别为5.0%(2/40)、10.0%(4/40),差异无统计学意义(P>0.05)。结论:芪地固肾方能有效改善DN患者的相关临床症状,使尿β2-微球蛋白、24 h尿蛋白定量、Cr和BUN水平明显降低,疗效显著。
OBJECTIVE:To retrospectively analyze the clinical effect and safety of Qidi Gushen recipe in the treatment of proteinuria in diabetic nephropathy(DN).METHODS:Total 80 patients diagnosed with DN of spleen and kidney Qi deficiency in the hospital from Jan.2019 to Jan.2022 were randomly divided into the observation group and the control group via the random grouping method,with 40 cases in each group.The control group was treated with conventional western medicine to control the disease,while the observation group received Qidi Gushen recipe orally bases on the control group for 2 months.The clinical efficacy,urinaryβ2-microglobulin,24 h urine microprotein,24 h urine protein quantification,blood creatinine(Cr)and urea nitrogen(BUN)levels and adverse drug reactions of two groups were observed after 8 weeks of treatment.RESULTS:After treatment,the levels of Cr,BUN,24 h urinary protein quantification and urinaryβ2-microglobulin in two groups decreased significantly,the differences were statistically significant(P<0.05).Compared with the control group,the levels of Cr,BUN,24 h urinary protein quantification and urinaryβ2-microglobulin in observation group decreased significantly,with statistically significant difference(P<0.05).The total effective rate of observation group was 65.0%(26/40),significantly higher than 35.0%(14/40)of control group,the difference was statistically significant(P<0.05).The incidence of adverse drug reactions in observation group and control group was respectively 5.0%(2/40)and 10.0%(4/40),with no statistically significant difference(P>0.05).CONCLUSIONS:The efficacy of Qidi Gushen recipe in the treatment of DN is significant,which can effectively improve the clinical symptoms,decrease the urinaryβ2-microglobulin,24 h urine microprotein,24 h urine protein quantification,Cr and BUN levels.
作者
周晓宇
雷根平
董盛
王婷
ZHOU Xiaoyu;LEI Genping;DONG Sheng;WANG Ting(The First Clinical Medical College,Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712046,China;Dept.of Nephropathy,Affiliated Hospital of Shaanxi University of Chinese Medicine,Shaanxi Xianyang 712000,China)
出处
《中国医院用药评价与分析》
2023年第11期1297-1300,共4页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
陕西省名中医雷根平传承工作室建设项目(No.2019012)
陕西中医药大学一流学科创新团队项目(No.2019-YL04)。
关键词
芪地固肾方
糖尿病肾病
蛋白尿
Qidi Gushen recipe
Diabetic nephropathy
Proteinuria
