摘要
神经退行性疾病(neurodegenerative diseases, NDs)是一类慢性、进行性发展的神经疾病,以特异性神经元的大量丢失为主要特征,主要包括阿尔茨海默病(Alzheimer’s disease, AD)、帕金森病(Parkinson’s disease, PD)、亨廷顿病(Huntington’s disease, HD)及肌萎缩性脊髓侧索硬化症(amyotrophic lateral sclerosis, ALS)等。虽然不同类型神经退行性疾病的病变部位和病因各不相同,但大脑特定区域的迟发性神经细胞退行性病变、神经元或突触丢失是它们的共同特征,因此统称为神经退行性疾病。由于神经退行性疾病的复杂性、多基因调控性,导致其病因和发病机制尚不明确,因此这类疾病的治疗举步维艰。近年来,斑马鱼(zebrafish)作为一种新型的模式生物,因其神经传导系统、神经元和神经胶质细胞类型及疾病相关基因同源性与人类都十分相似,受到越来越多的关注。目前,斑马鱼已广泛应用于神经退行性疾病的研究,并在此领域研究中已取得一定的成果,提高了我们对神经退行性疾病的认识。本文通过查阅近几年国内外相关文献,综述斑马鱼作为模式生物近年来在神经退行性疾病研究中的研究进展。
Neurodegenerative diseases are chronic and progressive neurological diseases characterized by loss of a large number of specific neurons.They mainly include Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,and amyotrophic lateral sclerosis.Although the lesions and etiologies of various types of neurodegenerative diseases are different,delayed neurodegenerative lesions and cell loss in specific brain areas are common characteristics.For this reason,they are collectively referred to as neurodegenerative diseases.In recent years,zebrafish have attracted increasing attention as a new type of model organism.Although some differences exist between zebrafish and human central nervous systems,zebrafish neural conduction systems,neuronal and glial cell types,and disease-related gene homology are very similar to those of humans.Zebrafish has been widely used to study neurodegenerative diseases,and some achievements have been made in this field to improve our understanding of these diseases.However,because of the complexity,multiple factors,and multi-gene regulation of neurodegenerative diseases,the etiology and pathogenesis of zebrafish are unclear.Therefore,treatment of this kind of disease has been difficult.By consulting the relevant literature from home and abroad in recent years,this artcile reviews recent advances in neurodegenerative diseases using zebrafish as a model organism.
作者
黄孔丽
苏世杰
王玉婷
刘壮壮
曹丹丹
汪沛
陈冠林
王奇
HUANG Kongli;SU Shijie;WANG Yuting;LIU Zhuangzhuang;CAO Dandan;WANG Pei;CHEN Guanlin;WANG Qi(Science and Technology Innovation Center,Guangzhou University of Chinese Medicine,Guangzhou 510405,China;Medical College of Acupuncture Moxibustion and Rehabilitation,Guangzhou University of Chinese Medicine,Guangzhou 510006;the Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510378)
出处
《中国比较医学杂志》
CAS
北大核心
2023年第10期121-131,共11页
Chinese Journal of Comparative Medicine
基金
国家自然科学基金面上项目(82274616)
广东省普通高校重点实验室项目(2019KSYS005)
广东省科技计划国际科技合作项目(2020A0505100052)。
关键词
斑马鱼
神经退行性疾病
模式生物
疾病模型
研究进展
zebrafish
neurodegenerative diseases
model organism
disease model
research progress Conflicts of Interest:The authors declare no conflict of interest.
