摘要
阿尔茨海默病(Alzheimer’s disease,AD)是一种病因未明且与年龄相关的不可逆性神经退行性疾病临床表现以认知和记忆功能丧失为主。目前,对于该病的发病机制及药物治疗效用的探索已成为现代脑科学研究的热点之一,但是其复杂的发生机制和病理学变化对实验动物模型的选择提出了重大挑战。本文就常用实验动物种类的特点、多种动物模型的甄选和模型构建方法进行了详细的评述。AD常用动物模型可分为自然动物模型、物理干预模型、化学干预模型、基因干预动物模型,以及其他类型。本文对这些模型构建方法、病理变化情况和适用实验类型进行总结和评述,希望能为研究者选用和建立实验动物模型提供参考。
Alzheimer’s disease(AD)is an irreversible and age-associated neurodegenerative disease with unclear etiology,and is characterized by a gradual loss of cognitive and memory functions.At present,investigation into the pathogenesis of AD and the efficacy of drug treatment has become one of the hotspots in the field of brain science.It is challenging to select proper experimental animal models of AD because of its complicated etiological mechanisms and pathological changes.This article gives a detailed review of the characteristics of multiple laboratory animals and related AD models,as well as the method of model construction.In general,AD animal models can be divided into natural,physical intervention,chemical intervention,genetic intervention,and other animal models.This paper has summarized and commented on the method of models’construction,the changes of pathology and applicable types of experiments,hoping to provide reference for researchers to select and establish experimental animal models.
作者
李少创
韩诚
秦亚莉
赵雅飞
魏文一
杨杰
帅月圆
郭栋
LI Shaochuang;HAN Cheng;QIN Yali;ZHAO Yafei;WEI Wenyi;YANG Jie;SHUAI Yueyuan;GUO Dong(Shanxi University of Traditional Chinese Medicine,Jinzhong 030619;China.2.Shanxi Key Laboratory of Chinese Medicine Encephalopathy,Jinzhong 030619)
出处
《中国实验动物学报》
CAS
CSCD
北大核心
2022年第1期131-145,共15页
Acta Laboratorium Animalis Scientia Sinica
基金
国家自然科学基金(81874420,81703959,82004236)
山西省教育厅自然科学类项目(2020L0405)。
关键词
阿尔茨海默病
动物模型
构建方法
评价
Alzheimer’s disease
animal models
construction method
evaluation
