摘要
目的加强医院慢性阻塞性肺疾病(COPD)常用药物超药品说明书用药管理。方法以“慢性阻塞性肺疾病”“超药品说明书用药”“噻托溴铵”“氨溴索”“茶碱类药物”等(及其对应的英文)为关键词,组合检索中国知网、万方、维普、PubMed等数据库中COPD常用药物超药品说明书用药相关文献,检索时限为各数据库自建库起至2023年8月,并汇总分析。参照《中国超药品说明书用药管理指南(2021)》《慢性阻塞性肺疾病临床诊治实施规范》《慢性阻塞性肺疾病诊治指南(2021年修订版)》等提出COPD常用药超药品说明书用药建议。结果共检索到国内外有效文献31篇,发现COPD常用药超药品说明书用药情况较普遍,涉及超适应证、超剂量、超给药途径、超禁忌证用药4种情况。结论建议完善呼吸内科超药品说明书用药相关管理制度,促进临床药师合理审核处方,强化医师对药品知识的学习,进一步规范COPD常用药物超药品说明书用药,更好地保障COPD患者的用药安全。
Objective To promote the management of off-label use of commonly used drugs for chronic obstructive pulmonary disease(COPD)in hospitals.Methods Literature related to the off-label use of commonly used drugs for COPD in the CNKI,WanFang,VIP and PubMed databases from the inception of each database to August 2023 were searched with″COPD″″off-label drug use″″tiotropium bromide″″ambroxol″″theophylline″and corresponding Chinese as the keywords,and the literature was analyzed.Based on the Guidelines for the Management of off-Label Drug Use in China(2021 Edition),Standards for Clinical Practice in Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease,and Guidelines for Clinical Diagnosis and Treatment of Chronic Obstructive Pulmonary Disease(Revised Edition 2021),the suggestions for off-label use of commonly used drugs for COPD were proposed.Results A total of 31 domestic and foreign valid literature was searched,and it was found that the off-label use of commonly used drugs for COPD was common,involving over indications,over doses,over administration routes and over contraindications.Conclusion It is suggested that we should improve the management system related to the off-label drug use in the respiratory department,promote the rational review of prescriptions by clinical pharmacists,strengthen the physicians′learning of drug knowledge,and further standardize the off-label use of commonly used drugs for COPD to better ensure the medication safety of patients with COPD.
作者
马萍
尤再春
MA Ping;YOU Zaichun(The Second Affiliated Hospital of Army Medical University,Chongqing,China 400037)
出处
《中国药业》
CAS
2023年第22期151-154,共4页
China Pharmaceuticals
基金
重庆市科卫联合医学科研项目[2020FYYX023]。
关键词
慢性阻塞性肺疾病
超药品说明书用药
文献分析
用药管理
chronic obstructive pulmonary disease
off-label drug use
literature analysis
medication management
