摘要
目的:调查分析四川省某三甲医院(以下简称"该院")呼吸内科门诊处方中超药品说明书用药情况,为该院超药品说明书用药情况提供参考,为国家制定超药品说明书用药政策提供基线数据。方法:随机抽取该院2015年门诊呼吸内科处方500张,用药记录共计1 234条。根据最新版药品说明书内容,判断是否超说明书用药,并分析超药品说明书用药类型及其比重;超药品说明书用药主要涉及的药品及比重。结果:超药品说明书用药处方112张,占22.40%;超药品说明书用药记录153条,占12.40%。超药品说明书用药类型中居前3位的是超适应症用药(69.94%)、超用法用量给药(28.76%)和超适用人群给药(0.65%)。超药品说明书用药药品类别中居前3位的是消化系统用药(37.25%)、抗感染药物(15.69%)和心血管系统用药(12.42%)。结论:该院呼吸内科超药品说明书用药情况居多,且多数为超适应症用药,正确的超药品说明书用药将有助于疾病的治疗,错误的超药品说明书用药会带来安全威胁。因此,规范超药品说明书用药,掌握正确的用药方法、途径,制定完善的法律政策,对疾病的防治有着重要的意义。
OBJECWIVE To investigate off-label drug use in outpatients with respiratory diseases in a 3A hospital （hereinaf- ter referred to as ＂this hospital＂） of Sichuan province, provide a reference and baseline data for making drug policy. METHODS Totally 500 prescriptions and 1 234 records in outpatients were collected in 2015. Relevant drug instructions were referred to estimate whether it belonged to off-label drug use. RESUL＇IS There were 112 （22. 4%） prescriptions of off-label drug use, 153 records （12. 40%） of off-label drug use. The top three reasons for off-label drug use were over indications （69. 94%）, over usage and dosage （28. 76%） and over applicable people （3.27%）. Main drugs in off-label use involved digestive system （37. 25%）, anti-infective medication （15.69M） and cardiovascular system （12. 42%）. CONCLUSION Off-label drug use in outpatients with respiratory diseases is very common in this hospital, mostly over indications. Off-label drug use should be ra- tional, so it is important to standardize the off-label drug use, master the correct methods and ways of using drugs, and estab- lish a perfect legal policy for disease prevention and treatment.
出处
《中国医院药学杂志》
CAS
北大核心
2017年第22期2300-2303,共4页
Chinese Journal of Hospital Pharmacy
关键词
超药品说明书用药
门诊处方
呼吸内科
用药记录
off-label drug use~ outpatient prescriptiom department of respiratory medicine~ medical records
