摘要
目的 优选温脾降糖颗粒提取工艺。方法 以煎煮次数、煎煮时间、加水量为考察因素,以黄芪甲苷、6-姜辣素含量、固形物质量为综合评价指标,采用L9(34)正交试验法优选温脾降糖颗粒提取工艺并验证。结果 温脾降糖颗粒最佳提取工艺为加6倍量水煎煮2次,每次1 h,固形物质量55.01 g,固形物得率为24.56%;成品中黄芪甲苷及6-姜辣素含量分别为67.59,149.84μg/mL。结论 该提取工艺稳定可行,重复性好,提取效率高;可用于温脾降糖颗粒的工业化生产。
Objective To optimize the extraction process of Wenpi Jiangtang Granules.Methods The extraction process of Wenpi Jiangtang Granules was optimized by the L9(34)orthogonal test,with the decoction frequency,decoction time and amount of water added as the investigation factors,and with the astragalosideⅣ,6-gingerol contents and solid mass as the comprehensive evaluation indicators,and then the verification test was conducted.Results The optimal extraction process of Wenpi Jiangtang Granules was as follows:adding six times the amount of water,decocting twice,each time for 1 h.The mass of solid was 55.01 g with the yield of 24.56%.The contents of astragalosideⅣand 6-gingerol in the finished product were 67.59,149.84μg/mL respectively.Conclusion The extraction process is stable,feasible,repeatable and efficient,which can be used for the industrial production of Wenpi Jiangtang Granules.
作者
陈雪婷
徐文杰
冯健英
李智勇
张建军
CHEN Xueting;XU Wenjie;FENG Jianying;LI Zhiyong;ZHANG Jianjun(Guangdong Second Hospital of Traditional Chinese Medicine·Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Technology·Guangdong Provincial Key Laboratory of Research and Development in Traditional Chinese Medicine,Guangzhou,Guangdong,China 510095)
出处
《中国药业》
CAS
2023年第22期53-56,共4页
China Pharmaceuticals
基金
国家中医药管理局2023年中医药部门中央补助资金(中药创新能力提升项目)[粤中医办函[2023]26号]
广东省科技计划项目[2017A070701017]。
关键词
温脾降糖颗粒
正交试验
黄芪甲苷
6-姜辣素
提取工艺
Wenpi Jiangtang Granules
orthogonal test
astragalosideⅣ
6-gingerol
extraction process
