摘要
目的:探讨上皮样胶质母细胞瘤(ep-GBM)患者的临床特征及其生存时间的影响因素。方法:选择郑州大学第一附属医院神经外科自2015年8月至2022年3月采用手术治疗的16例ep-GBM患者为研究对象。采用Kaplan-Meier法绘制患者的生存曲线,比较不同临床特征患者无进展生存期(PFS)、总生存期(OS)的差异,采用Log-rank检验比较不同患者生存率、无进展生存率的差异,构建Cox比例风险回归模型分析患者PFS及OS的影响因素。结果:16例患者的中位OS为11.8个月,中位PFS为7.0个月。年龄<32岁组与年龄≥32岁组、肿瘤最大径<4.8 cm组与肿瘤最大径≥4.8 cm组,p53表达阳性组与p53表达阴性组患者PFS、OS的差异均有统计学意义(P<0.05)。Log-rank检验显示年龄<32岁组与年龄≥32岁组、肿瘤最大径<4.8 cm组与肿瘤最大径≥4.8 cm组、S100表达阳性组与S100表达阴性组、少突胶质细胞转录因子2(Olig-2)表达阳性组与Olig-2表达阴性组、p53表达阳性组与p53表达阴性组患者的生存率、无进展生存率不同,差异均有统计学意义(P<0.05)。Cox比例风险回归模型分析结果显示,年龄(HR=1.070,95%CI:1.013~1.134,P=0.016)、术前肿瘤最大径(HR=2.150,95%CI:1.142~4.055,P=0.018)、Olig-2表达(HR=0.040,95%CI:0.003~0.498,P=0.013)对患者的PFS有影响;术前肿瘤最大径(HR=2.350,95%CI:1.149~4.798,P=0.019)、Olig-2表达(HR=0.080,95%CI:0.007~0.972,P=0.047)对患者的OS有影响。结论:年龄较大的ep-GBM患者术后进展风险高,肿瘤最大径较大、Olig-2表达阴性的ep-GBM患者术后不仅进展风险高且生存期短。
Objective To investigate the clinical characteristics of patients with epithelioid glioblastoma(ep-GBM)and their influencing factors for survival.Methods Sixteen ep-GBM patients admitted to Department of Neurosurgery,First Affiliated Hospital of Zhengzhou University from August 2015 to March 2022 were chosen.Clinical data such as age,gender,maximum tumor diameter,degrees of tumor resection,treatments,and immunohistochemical staining-related indexes were obtained.Survival curves of the patients were plotted by Kaplan-Meier method,and differences of progression-free survival(PFS)and overall survival(OS)among patients with different clinical characteristics were compared.Log-rank test was used to compare the survival rates,and Cox proportional risk regression model was constructed to analyze the influencing factors for PFS and OS.Results In these 16 patients,median OS was 11.8 months and median PFS was 7.0 months.Significant differences in PFS and OS were noted between groups of age<32 years and age≥32 years,between groups of maximum tumor diameter<4.8 cm and diameter≥4.8 cm,and between groups of positive p53 expression and negative p53 expression(P<0.05).Log-rank test indicated that OS and PFS ratios were significantly different between groups of age<32 years and age≥32 years,between groups of maximum tumor diameter<4.8 cm and diameter≥4.8 cm,between S100 positive group and S100 negative group,between Olig-2 positive group and Olig-2 negative group,and between groups of positive p53 expression and negative p53 expression(P<0.05).Cox proportional hazard regression model showed that age(HR=1.070,95%CI:1.013-1.134,P=0.016),preoperative maximum tumor diameter(HR=2.150,95%CI:1.142-4.055,P=0.018)and Olig-2 expression(HR=0.040,95%CI:0.003-0.498,P=0.013)had influences in PFS;preoperative maximum tumor diameter(HR=2.350,95%CI:1.149-4.798,P=0.019)and Olig-2 expression(HR=0.080,95%CI:0.007-0.972,P=0.047)had influences in OS.Conclusion Older ep-GBM patients are prone to progress after surgery;ep-GBM patients with large
作者
周丽丽
朱聪聪
安吉洋
曲甜甜
Zhou Lili;Zhu Congcong;An Jiyang;Qu Tiantian(Department of Oncology,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Neurosurgery,First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China)
出处
《中华神经医学杂志》
CAS
CSCD
北大核心
2023年第10期1001-1009,共9页
Chinese Journal of Neuromedicine
基金
国家自然科学基金(81802929)。
关键词
上皮样胶质母细胞瘤
生存分析
临床特征
预后
Epithelioid glioblastoma
Survival analysis
Clinic characteristic
Prognosis